Arjun S. Adhikari

Cardiovascular Institute of the South — United States

Medicine · Health Sciences

16h-index1.5kcitations39works0.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Cardiomyopathy and Myosin Studies(22), Cardiovascular Effects of Exercise(13), Cellular Mechanics and Interactions(11), Muscle Physiology and Disorders(11), Congenital heart defects research(6)

Publications39 total

The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin
Science Advances·2020· 96 citedOpen Access
Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties
Journal of Biological Chemistry·2019· 40 citedOpen Access
Abstract 212: Hypertrophic Cardiomyopathy Mutations With Opposite Effects on ß-myosin Biomechanics Show Similar Structural and Biomechanical Phenotypes in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (hipsc-cms)
Circulation Research·2019
β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
Nature Communications·2019· 86 citedOpen Access
Myosin motor domains carrying mutations implicated in early or late onset Hypertrophic Cardiomyopathy have similar properties
2019Open Access
The molecular basis of hypercontractility caused by the hypertrophic cardiomyopathy mutations R403Q and R663H
2019· 2 citedOpen Access
On the Functional Assessment of Hypertrophic Cardiomyopathy-Causing Mutations in Human β-Cardiac Myosin and the Role of Myosin Binding Protein-C
Biophysical Journal·2019Open Access
Hypertrophic cardiomyopathy mutations at the folded-back sequestered β-cardiac myosin S1-S2 and S1-S1 interfaces release sequestered heads and increase myosin enzymatic activity
2019· 6 citedOpen Access
A Molecular Approach to Understand the Super-Relaxed State of Myosin Observed in Cardiac Muscle
Biophysical Journal·2018Open Access
Mechanobiology of Myosin Mutations and Myofibril Remodeling in iPSC-Cardiomyocytes
Biophysical Journal·2018Open Access
Hypertrophic Cardiomyopathy Mutations Disrupt Human Beta Cardiac Myosin Intramolecular Interactions Leading to Increased Myosin Activity
Biophysical Journal·2018Open Access
Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light
Biophysical Reviews·2017· 158 citedOpen Access
A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix
Molecular Biology of the Cell·2017· 71 cited
The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
Nature Structural & Molecular Biology·2017· 225 citedOpen Access
Uncovering the Molecular Interactions that Maintain the Sequestered State of Myosin and their Implication in Hypertrophic Cardiomyopathy
Biophysical Journal·2017Open Access
Investigation of the Molecular Interactions Regulating the Function of Human Cardiac Myosin
Biophysical Journal·2017Open Access
Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin
Cell Reports·2016· 91 citedOpen Access
Mutations in the catalytic domain of human β-cardiac myosin that cause early onset hypertrophic cardiomyopathy significantly increase the fundamental parameters that determine ensemble force and velocity
2016· 1 citedOpen Access
Cytoskeletal and Adhesion Dynamics are Coupled to Matrix Deformation in 3D Cell Migration
Biophysical Journal·2016Open Access
The Effect of Pediatric Specific Hypertrophic Cardiomyopathy Mutations on the Biomechanics of Beta Cardiac Myosin
Biophysical Journal·2016Open Access
page 1 of 2Next →

Frequent Co-authors

Kathleen M. Ruppel(21), James A. Spudich(21), Alexander R. Dunn(15), Saswata S. Sarkar(15), Darshan V. Trivedi(13), Kristina B. Kooiker(8), Daniel Bernstein(8), Shirley Sutton(7), Armen H. Mekhdjian(6), Chao Liu(6), Leanna M. Owen(5), Natascha Leijnse(5), Masatoshi Morimatsu(4), Suman Nag(4), Jack Chai(4), Makenna M. Morck(4), R. E. Taylor(3), Min Cheol Kim(3), Leslie A. Leinwand(3), Shaik Pasha(2)