John T. Gupton

University of Richmond — United States

Chemistry · Physical Sciences

28h-index2.1kcitations187works0.02yr avg
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Research Topics

Synthesis and Characterization of Pyrroles(45), Synthesis and Reactions of Organic Compounds(38), Fluorine in Organic Chemistry(37), Synthesis and Biological Evaluation(31), Asymmetric Synthesis and Catalysis(28)

Publications187 total

Effects of Poly‐Substituted Pyrroles on Pro‐Inflammatory Signaling in RAW264.7 Macrophages
The FASEB Journal·2022
Application of vinylogous carbamates and vinylogous aminonitriles to the regiospecific synthesis of uniquely functionalized pyrroles and quinolones
Tetrahedron·2018· 13 cited
Further studies on the application of vinylogous amides and β-halovinylaldehydes to the regiospecific synthesis of unsymmetrical, polyfunctionalized 2,3,4- and 1,2,3,4- substituted pyrroles
Tetrahedron·2018· 6 citedOpen Access
Effects of a novel microtubule-depolymerizer on pro-inflammatory signaling in RAW264.7 macrophages
Chemico-Biological Interactions·2017· 7 citedOpen Access
Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities
Bioorganic & Medicinal Chemistry·2017· 4 citedOpen Access
Effects of a pyrrole-based, microtubule-depolymerizing compound on RAW 264.7 macrophages
Chemico-Biological Interactions·2016· 5 citedOpen Access
Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design
Molecular Pharmacology·2015· 10 citedOpen Access
ChemInform Abstract: The Application of Formyl Group Activation of Bromopyrrole Esters to Formal Syntheses of Lycogarubin C, Permethyl Storniamide A and Lamellarin G Trimethyl Ether.
ChemInform·2015
The application of formyl group activation of bromopyrrole esters to formal syntheses of lycogarubin C, permethyl storniamide A and lamellarin G trimethyl ether
Tetrahedron·2014· 10 citedOpen Access
ChemInform Abstract: Formyl Group Activation of a Bromopyrrole Ester in Suzuki Cross‐Coupling Reactions: Application to a Formal Synthesis of Polycitone A and B and Polycitrin A.
ChemInform·2014
Formyl group activation of a bromopyrrole ester in Suzuki cross-coupling reactions: application to a formal synthesis of Polycitone A and B and Polycitrin A
Tetrahedron·2014· 4 citedOpen Access
ChemInform Abstract: Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles.
ChemInform·2013
How to Deal with Low-Resolution Target Structures: Using SAR, Ensemble Docking, Hydropathic Analysis, and 3D-QSAR to Definitively Map the αβ-Tubulin Colchicine Site
Journal of Medicinal Chemistry·2013· 38 citedOpen Access
Preparation of indole containing building blocks for the regiospecific construction of indole appended pyrazoles and pyrroles
Tetrahedron·2013· 15 citedOpen Access
Developing novel C-4 analogues of pyrrole-based antitubulin agents: weak but critical hydrogen bonding in the colchicine site
MedChemComm·2012· 18 citedOpen Access
Autophagy, cell death and sustained senescence arrest in B16/F10 melanoma cells and HCT-116 colon carcinoma cells in response to the novel microtubule poison, JG-03-14
Cancer Chemotherapy and Pharmacology·2012· 30 cited
Pyrrole-Based Antitubulin Agents: Two Distinct Binding Modalities Are Predicted for C-2 Analogues in the Colchicine Site
ACS Medicinal Chemistry Letters·2011· 24 cited
ChemInform Abstract: The Application of (Z)‐3‐Aryl‐3‐haloenoic Acids to the Synthesis of (Z)‐5‐Benzylidene‐4‐arylpyrrol‐2(5H)‐ones.
ChemInform·2011
ChemInform Abstract: Further Studies on Vinamidinium Salt Amine Exchange Reactions, Borohydride Reductions, and Subsequent Transformations.
ChemInform·2011
The application of (Z)-3-aryl-3-haloenoic acids to the synthesis of (Z)-5-benzylidene-4-arylpyrrol-2(5H)-ones
Tetrahedron·2010· 17 cited
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Frequent Co-authors

James A. Sikorski(16), Keith E. Krumpe(8), Scott A. Petrich(7), R. P. F. Kanters(6), Bruce S. Burnham(6), Glen E. Kellogg(5), John P. Idoux(5), Karen Du(5), Susan L. Mooberry(5), Edith J. Banner(5), David A. Gewirtz(4), Cesar Colon(4), Peter Barelli(4), Jonathan E. Hempel(4), Fred A. Hicks(4), Robert B. Miller(4), Steve W. Riesinger(3), Hiroki Yamanaka(3), Takashi Ishihara(3), Phong Vu(3)