Mario Huesca

Medicine · Health Sciences

18h-index1.2kcitations29works0.02yr avg
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Research Topics

Helicobacter pylori-related gastroenterology studies(9), Kruppel-like factors research(7), Veterinary medicine and infectious diseases(6), Trace Elements in Health(5), Antimicrobial Resistance in Staphylococcus(3)

Publications29 total

Data from A novel small molecule with potent anticancer activity inhibits cell growth by modulating intracellular labile zinc homeostasis
2023Open Access
Data from A novel small molecule with potent anticancer activity inhibits cell growth by modulating intracellular labile zinc homeostasis
2023Open Access
Supplementary Data from A novel small molecule with potent anticancer activity inhibits cell growth by modulating intracellular labile zinc homeostasis
2023Open Access
Supplementary Data from A novel small molecule with potent anticancer activity inhibits cell growth by modulating intracellular labile zinc homeostasis
2023Open Access
Abstract 3710: Preclinical dose scheduling studies of LOR-253, a novel anticancer drug, in combination with chemotherapeutics in lung and colon cancers
Cancer Research·2012· 1 cited
Abstract 667: Anticancer activity and tumor selectivity of LOR-253, a novel drug candidate, in lung carcinoma
Cancer Research·2011
Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus
Bioorganic & Medicinal Chemistry Letters·2010· 37 cited
A novel small molecule with potent anticancer activity inhibits cell growth by modulating intracellular labile zinc homeostasis
Molecular Cancer Therapeutics·2009· 31 cited
Abstract #1822: Mechanistic studies of a novel small molecule anticancer drug, LOR-253, on cell cycle arrest and angiogenesis
Cancer Research·2009
A novel zinc-chelating small molecule exhibits cancer cell growth inhibition <i>in vitro</i> and <i>in vivo</i> by induction of tumor suppressors early growth response 1 (Egr-1) and Krüppel-Like Factor 4 (KLF4)
Journal of Clinical Oncology·2007
Liposome formulation of a novel hydrophobic aryl-imidazole compound for anti-cancer therapy
Cancer Chemotherapy and Pharmacology·2005· 48 cited
Adhesion and Virulence Properties of Epidemic Canadian Methicillin‐Resistant<i>Staphylococcus aureus</i>Strain 1: Identification of Novel Adhesion Functions Associated with Plasmin‐Sensitive Surface Protein
The Journal of Infectious Diseases·2002· 41 citedOpen Access
Variance in Fibronectin Binding and <i>fnb</i> Locus Polymorphisms in <i>Staphylococcus aureus</i> : Identification of Antigenic Variation in a Fibronectin Binding Protein Adhesin of the Epidemic CMRSA-1 Strain of Methicillin-Resistant <i>S. aureus</i>
Infection and Immunity·2001· 40 citedOpen Access
Enterohemorrhagic<i>Escherichia coli</i>Induces Apoptosis Which Augments Bacterial Binding and Phosphatidylethanolamine Exposure on the Plasma Membrane Outer Leaflet
Infection and Immunity·2000· 78 cited
Synthetic Peptide Immunogens Elicit Polyclonal and Monoclonal Antibodies Specific for Linear Epitopes in the D Motifs of <i>Staphylococcus aureus</i> Fibronectin-Binding Protein, Which Are Composed of Amino Acids That Are Essential for Fibronectin Binding
Infection and Immunity·2000· 30 cited
Phosphatidylethanolamine recognition promotes enteropathogenic E. coli and enterohemorrhagic E. coli host cell attachment
Microbial Pathogenesis·1999· 61 cited
Characterization of an Acidic-pH-Inducible Stress Protein (hsp70), a Putative Sulfatide Binding Adhesin, from<i>Helicobacter pylori</i>
Infection and Immunity·1998· 79 citedOpen Access
Inhibition of Helicobacter pylori and Helicobacter mustelae Binding to Lipid Receptors by Bovine Colostrum
The Journal of Infectious Diseases·1998· 53 citedOpen Access
Characterization of an Acidic-pH-Inducible Stress Protein (hsp70), a Putative Sulfatide Binding Adhesin, fromHelicobacter pylori
Infection and Immunity·1998
Acidic pH changes receptor binding specificity of Helicobacter pylori: a binary adhesion model in which surface heat shock (stress) proteins mediate sulfatide recognition in gastric colonization
Infection and Immunity·1996· 144 citedOpen Access
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Frequent Co-authors

Clifford A. Lingwood(12), Aiping Young(10), Hongnan Jin(9), Robert Peralta(8), Yoon Lee(8), Philip M. Sherman(6), Raed A. Al‐Qawasmeh(6), Lisa Lock(6), Aye Aye Khine(6), Stéphane Viau(5), I. Howard Cukier(5), B. D. Gold(4), Robert L. Peralta(4), Jim Wright(4), Paul S. Hoffman(3), Dana J. Philpott(3), Martin J. McGavin(3), Venkata Nedunuri(3), Howard Cukier(3), A. Kuksis(2)