Margaret Fahnestock

McMaster University — Canada

Neuroscience · Life Sciences

57h-index12.2kcitations201works1.22yr avg
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Research Topics

Nerve injury and regeneration(78), Neurogenesis and neuroplasticity mechanisms(51), Alzheimer's disease research and treatments(39), Axon Guidance and Neuronal Signaling(18), Neuroscience and Neuropharmacology Research(17)

Publications199 total

Nitrative stress activates JNK and decreases retrograde transport of brain‐derived neurotrophic factor in basal forebrain cholinergic neurons
Alzheimer s & Dementia·2025Open Access
Gonadal hormones contribute to sex differences in behavior, pathology and epigenetic modifications in the 3×Tg-AD mouse model of Alzheimer’s disease
Biology of Sex Differences·2025Open Access
Nutrient sensing receptor GPRC6A regulates mTORC1 signaling and Tau biology
Neurobiology of Disease·2025Open Access
Muscle-brain crosstalk as a driver of brain health in aging
GeroScience·2025· 1 citedOpen Access
Pain informed movement compared to neuromuscular exercise and standard education in people with knee osteoarthritis: A pilot and feasibility randomized controlled trial
Osteoarthritis and Cartilage Open·2025Open Access
Opposing effects of histone H2A.Z on memory, transcription and pathology in male and female Alzheimer’s disease mice and patients
2025· 1 citedOpen Access
Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer’s disease mouse model
Cell Death and Disease·2025· 5 citedOpen Access
FEASIBILITY AND preliminary EFFECTIVENESS OF Pain Informed Movement for KNEE OSTEOARTHRITIS: A Pilot RANDOMIZED controlled TRIAL
Osteoarthritis and Cartilage·2025
The Effects of Electrical Stimulation on a 3D Osteoblast Cell Model
Cells·2025· 1 citedOpen Access
Engaging older adults in the process of aging research: a multimethod study evaluating the experience and efficacy of a citizen advisory group for a dementia risk reduction program
Research Involvement and Engagement·2024· 3 citedOpen Access
Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)
Journal of Alzheimer s Disease·2024· 5 cited
Epigenetic derepression of H3K9me3 mitigates Alzheimer-related pathology and improves cognition via immunomodulation and Vgf induction
2024Open Access
Nutrient Sensing Receptor GPRC6A Regulates mTORC1 Signaling and Tau Biology
2024· 1 citedOpen Access
Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer’s disease mouse model
2024· 1 citedOpen Access
Combining AlphaFold and molecular dynamics simulations to determine the complete structures of isoforms of human brain-derived neurotrophic factor and human nerve growth factor
Biophysical Journal·2024
Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75NTR
Frontiers in Molecular Neuroscience·2023· 4 citedOpen Access
Mechanisms of the Beneficial Effects of Exercise on Brain-Derived Neurotrophic Factor Expression in Alzheimer’s Disease
Biomolecules·2023· 46 citedOpen Access
The Effects of Exercise on Synaptic Plasticity in Individuals With Mild Cognitive Impairment: Protocol for a Pilot Intervention Study
JMIR Research Protocols·2023· 3 citedOpen Access
Mechanisms of the Beneficial Effects of Exercise on Brain-Derived Neurotrophic Factor Expression in Alzheimer’s Disease
Preprints.org·2023· 12 citedOpen Access
Feasibility of pain informed movement program for people with knee osteoarthritis
Osteoarthritis and Cartilage Open·2023· 5 citedOpen Access
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Frequent Co-authors

Bernadeta Michalski(14), Guanhua Yu(6), Shiyong Peng(4), Elliott J. Mufson(4), Chiara Nicolini(4), Michael D. Coughlin(4), James R. Bain(4), Ronald J. Racine(3), Diego J. Garzon(3), Stephen D. Ginsberg(3), Beverly M. Francis(3), Howard T.J. Mount(3), Elyse Rosa(3), B. Michalski(3), R. Racine(3), Joanne Wuu(2), Bin Xu(2), R. M. Damian Holsinger(2), Monica Marchese(2), Glenda MacQueen(2)