Daphne C. Clancy

Alcon (United States) — United States

Chemistry · Physical Sciences

5h-index52citations5works0.02yr avg
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Research Topics

Carbohydrate Chemistry and Synthesis(4), Glycogen Storage Diseases and Myoclonus(4), Diabetes Treatment and Management(3), Ocular Surface and Contact Lens(1), Mast cells and histamine(1)

Publications5 total

Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility
Journal of Medicinal Chemistry·2023· 7 citedOpen Access
Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy
Bioorganic & Medicinal Chemistry Letters·2008· 20 citedOpen Access
Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes: 1. Identification of 1-amino-1-cycloalkyl carboxylic acid headgroups
Bioorganic & Medicinal Chemistry Letters·2008· 7 citedOpen Access
Anthranilimide-based glycogen phosphorylase inhibitors for the treatment of Type 2 diabetes: 2. Optimization of serine and threonine ether amino acid residues
Bioorganic & Medicinal Chemistry Letters·2008· 7 citedOpen Access
Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors
Bioorganic & Medicinal Chemistry Letters·2008· 11 citedOpen Access

Frequent Co-authors

Stephen A. Thomson(4), Francis X. Tavares(4), James E. Weiel(4), Pierette Banker(3), D. Mark Bickett(3), Scott H. Dickerson(3), Dulce Garrido(3), Andrew J. Peat(3), Lauren R. Sheckler(3), Steven M. Sparks(3), Pamela L. Golden(3), Joyce A. Boucheron(2), Robert T. Nolte(2), H. Luke Carter(1), Joel P. Cooper(1), Liping Wang(1), Tony Y. Wang(1), Karen A. Evans(1), Yue H. Li(1), Frank T. Coppo(1)