Frances H. Arnold

California Institute of Technology — United States

Earth and Planetary Sciences · Physical Sciences

138h-index70.2kcitations912works12.32yr avg
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Research Topics

Atmospheric chemistry and aerosols(182), Atmospheric Ozone and Climate(153), Enzyme Catalysis and Immobilization(150), Microbial Metabolic Engineering and Bioproduction(107), Cyclopropane Reaction Mechanisms(96)

Publications912 total

A Chemoselective and Stereodivergent Platform of Heme‐Nitrene Transferases to Access Chiral Aryl‐β‐Amino Esters and An Investigation of the Sequence‐Activity Landscape
Angewandte Chemie International Edition·2026
A unified pipeline for discovering previously unknown enzyme activities
2026Open Access
Sequence-based generative AI design of versatile tryptophan synthases
Nature Communications·2026Open Access
Squidly: Enzyme Catalytic Residue Prediction Harnessing a Biology-Informed Contrastive Learning Framework
2026Open Access
A Biocatalytic Platform for the Synthesis of Organofunctional Silanes and Siloxanes
Angewandte Chemie International Edition·2025
A Biocatalytic Platform for the Synthesis of Organofunctional Silanes and Siloxanes
Angewandte Chemie·2025
Self Distillation Fine-Tuning of Protein Language Models Improves Versatility in Protein Design
arXiv (Cornell University)·2025Open Access
Enzyme Engineering Database (EnzEngDB): a platform for sharing and interpreting sequence–function relationships across protein engineering campaigns
Nucleic Acids Research·2025· 1 citedOpen Access
Squidly: Enzyme Catalytic Residue Prediction Harnessing a Biology-Informed Contrastive Learning Framework
2025Open Access
Squidly: Enzyme Catalytic Residue Prediction Harnessing a Biology-Informed Contrastive Learning Framework
2025· 2 citedOpen Access
Evaluation of machine learning-assisted directed evolution across diverse combinatorial landscapes
Cell Systems·2025· 2 cited
Sequence-Based Generative AI-Guided Design of Versatile Tryptophan Synthases
2025Open Access
Illuminating the universe of enzyme catalysis in the era of artificial intelligence
Cell Systems·2025· 2 cited
Anhedonic versus dysphoric cognitive profiles for depression: a latent profile analysis of attention, processing, and memory biases for positive versus dysphoric stimuli in depressed individuals
2025Open Access
Enzymatic Stereodivergent Synthesis of Azaspiro[2.y]alkanes
Journal of the American Chemical Society·2025· 5 cited
Invest in data resources to make FAIR a reality
Nature·2025· 1 cited
Squidly: Enzyme Catalytic Residue Prediction Harnessing a Biology-Informed Contrastive Learning Framework
2025Open Access
Steering Generative Models with Experimental Data for Protein Fitness Optimization
arXiv (Cornell University)·2025Open Access
Enzymatic Stereodivergent Synthesis of Azaspiro[2.y]alkanes
2025· 2 citedOpen Access
Active learning-assisted directed evolution
Nature Communications·2025· 50 citedOpen Access
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Frequent Co-authors

Jesse D. Bloom(5), Stephen R. Quake(4), Lingchong You(4), Ron Weiss(3), Kai Chen(3), Pedro S. Coelho(3), Christopher R. Otey(2), Cynthia H. Collins(2), Philip A. Romero(2), Anne Y. Fu(2), Charles Spence(2), D. Allan Drummond(2), Christoph Adami(2), Claus O. Wilke(2), Eric M. Brustad(2), Arvind Kannan(2), Lori Giver(2), Frederick Balagadde(2), Zachary Wu(2), S. B. Jennifer Kan(2)