Richard McCulloch

Wellcome Centre for Molecular Parasitology — United Kingdom

Medicine · Health Sciences

43h-index6.9kcitations152works2.52yr avg
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Research Topics

Trypanosoma species research and implications(118), Research on Leishmaniasis Studies(80), Biochemical and Molecular Research(29), CRISPR and Genetic Engineering(24), Plant Virus Research Studies(22)

Publications150 total

De novo assembly of the <i>Trypanosoma congolense</i> genome reveals an organisation influenced by antigenic variation but distinct from <i>Trypanosoma brucei</i>
2026Open Access
Reduced levels of inositol hexakisphosphate kinase (IP6K) impair life-cycle transitions and the intracellular development of <i>Trypanosoma cruzi</i> within human cardiomyocytes
2026Open Access
ATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major
PLoS Genetics·2025Open Access
MBP - Journal scope update
Molecular and Biochemical Parasitology·2025
Leishmania major chromosomes are replicated from a single high-efficiency locus supplemented by thousands of lower efficiency initiation events
Cell Reports·2025· 1 citedOpen Access
TrAGEDy—trajectory alignment of gene expression dynamics
Bioinformatics·2025· 2 citedOpen Access
R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania
Nature Communications·2025· 9 citedOpen Access
Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei
Nature Communications·2025· 5 citedOpen Access
ATR, a DNA damage kinase, modulates DNA replication timing in <i>Leishmania major</i>
2025Open Access
Genome-Wide Mapping of RPA1 and RAD9 Reveals the Management of Polycistronic Transcription, Replication Initiation, and Responses to Replication Stress in Leishmania
SSRN Electronic Journal·2025Open Access
AUK3 is required for faithful nuclear segregation in the bloodstream form of Trypanosoma brucei
Molecular and Biochemical Parasitology·2024· 1 citedOpen Access
Do tissue-dwelling trypanosomes sustain transmission populations?
Trends in Parasitology·2024Open Access
Nuclear DNA replication in <i>Leishmania major</i> relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events
2024· 1 citedOpen Access
Genome-wide mapping of RPA1 and RAD9 reveals the management of polycistronic transcription, replication initiation, and responses to replication stress in <i>Leishmania</i>
2024· 2 citedOpen Access
AUK3 is required for faithful nuclear segregation in the bloodstream form of <i>Trypanosoma brucei</i>
2024Open Access
Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in <i>Trypanosoma brucei</i>
2024· 4 citedOpen Access
R-loops acted on by RNase H1 are a determinant of chromosome length-associated DNA replication timing and genome stability in <i>Leishmania</i>
2024· 3 citedOpen Access
Ancestral aneuploidy and stable chromosomal duplication resulting in differential genome structure and gene expression control in trypanosomatid parasites
Genome Research·2024· 19 citedOpen Access
Nuclear DNA Replication in Leishmania major Relies on a Single Constitutive Origin per Chromosome Supplemented by Thousands of Stochastic Initiation Events
SSRN Electronic Journal·2024· 2 citedOpen Access
RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation in <i>Trypanosoma brucei</i>
Proceedings of the National Academy of Sciences·2023· 20 citedOpen Access
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Frequent Co-authors

J. David Barry(10), Peter Burton(5), David Horn(5), David J. Sherratt(5), Emma M. Briggs(5), Catarina A. Marques(5), Jeremy C. Mottram(4), Gloria Rudenko(4), Lucio Marcello(4), Calvin Tiengwe(4), Daniel Paape(4), Craig Lapsley(4), Sean D. Colloms(3), Liam J. Morrison(3), Nicholas J. Dickens(3), Colin Conway(3), Leandro Lemgruber(3), Kathryn Crouch(3), Jeziel D. Damasceno(3), Daniella Castanheira Bartholomeu(2)