W. Seth Horne

University of Pittsburgh — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

39h-index6.1kcitations179works0.92yr avg
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Research Topics

Chemical Synthesis and Analysis(83), Click Chemistry and Applications(34), Protein Structure and Dynamics(24), Biochemical and Structural Characterization(22), RNA and protein synthesis mechanisms(19)

Publications179 total

Backbone engineering in the hydrophobic core of villin headpiece
RSC Chemical Biology·2025Open Access
Impact of Strand Edge N-Amination on the Stability of a Parallel β-Hairpin Fold
The Journal of Organic Chemistry·2025· 1 citedOpen Access
A Predictive Model for Thiol Reactivity of <i>N</i>-Heteroaryl α-Methylene−γ-Lactams─A Medicinally Relevant Covalent Reactive Group
Journal of Medicinal Chemistry·2025· 1 citedOpen Access
A predictive model for thiol reactivity of N-heteroaryl α-methylene–γ-lactams—a medicinally relevant covalent reac-tive group
2025
Stabilization of a miniprotein fold by an unpuckered proline surrogate
Communications Chemistry·2025· 1 citedOpen Access
Interplay between C<sub>α</sub> Methylation and C<sub>α</sub> Stereochemistry in the Folding Energetics of a Helix‐Rich Miniprotein
ChemBioChem·2025· 1 citedOpen Access
Structural and Functional Mimicry of the Antimicrobial Defensin Plectasin by Analogues with Engineered Backbone Composition
ChemBioChem·2024· 2 citedOpen Access
Stabilization of a miniprotein fold by an unpuckered proline surrogate
2024Open Access
Cover Feature: Backbone Modification in a Protein Hydrophobic Core (Chem. Eur. J. 45/2024)
Chemistry - A European Journal·2024Open Access
Application of artificial backbone connectivity in the development of metalloenzyme mimics
Current Opinion in Chemical Biology·2024· 1 citedOpen Access
Backbone Modification in a Protein Hydrophobic Core
Chemistry - A European Journal·2024· 3 citedOpen Access
Probing effects of site‐specific aspartic acid isomerization on structure and stability of <scp>GB1</scp> through chemical protein synthesis
Protein Science·2023· 5 citedOpen Access
Effects of altered backbone composition on the folding kinetics and mechanism of an ultrafast-folding protein
Chemical Science·2023· 5 citedOpen Access
Front Cover: Protein Backbone Alteration in Non‐Hairpin β‐Turns: Impacts on Tertiary Folded Structure and Folded Stability (ChemBioChem 11/2023)
ChemBioChem·2023Open Access
Protein Backbone Alteration in Non‐Hairpin β‐Turns: Impacts on Tertiary Folded Structure and Folded Stability
ChemBioChem·2023· 2 citedOpen Access
Effects of chirality and side chain length in C<sub>α,α</sub>-dialkylated residues on β-hairpin peptide folded structure and stability
Organic & Biomolecular Chemistry·2023· 2 citedOpen Access
Chemical shifts of artificial monomers used to construct <scp>heterogeneous‐backbone</scp> protein mimetics in random coil and folded states
Peptide Science·2022Open Access
Benchmarking Chiral Induced Spin Selectivity Measurements ‐ Towards Meaningful Comparisons of Chiral Biomolecule Spin Polarizations
Israel Journal of Chemistry·2022· 37 cited
Heterogeneous-Backbone Proteomimetic Analogues of Lasiocepsin, a Disulfide-Rich Antimicrobial Peptide with a Compact Tertiary Fold
ACS Chemical Biology·2022· 10 citedOpen Access
Implications of the unfolded state in the folding energetics of heterogeneous-backbone protein mimetics
Chemical Science·2022· 10 citedOpen Access
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Frequent Co-authors

Samuel H. Gellman(13), M. Reza Ghadiri(10), George A. Lengyel(6), Zachary E. Reinert(5), Joshua L. Price(4), John M. Beierle(4), Lisa M. Johnson(3), Timothy F. Cunningham(3), Sunil Saxena(3), Jan H. van Maarseveen(3), Conor M. Haney(3), Thomas J. Ketas(2), Min Lu(2), John P. Moore(2), Nurit Ashkenasy(2), Miriam R. Putterman(2), Astha Desai(2), Halina M. Werner(2), Christian A. Olsen(2), Ana Montero(2)