Robert L. Smith

Johns Hopkins University — United States

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

62h-index15.1kcitations381works3.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(44), Metabolism and Genetic Disorders(40), Schizophrenia research and treatment(39), Drug Transport and Resistance Mechanisms(34), Carcinogens and Genotoxicity Assessment(20)

Publications381 total

Impact of the transcription factor nuclear factor 1 B T>C polymorphism on clozapine metabolism in vivo and expression of intestinal transporters in vitro
Drug Metabolism and Disposition·2025· 1 citedOpen Access
The effectiveness of an educational intervention to introduce adolescents from marginalized backgrounds to dermatology: A pilot initiative
Journal of the American Academy of Dermatology·2025Open Access
Correlation Between Clozapine and <scp>CRP</scp> Levels in Relation to Smoking Status
Acta Psychiatrica Scandinavica·2025· 7 citedOpen Access
Author response for "Correlation Between Clozapine and &lt;scp&gt;CRP&lt;/scp&gt; Levels in Relation to Smoking Status"
2025
Polygenic overlap with granulocyte counts identifies novel loci for clozapine metabolism and clozapine-induced agranulocytosis
Neuropsychopharmacology·2025· 2 cited
Acute oral digoxin in healthy adults hastens fatigue and increases plasma K<sup>+</sup> during intense exercise, despite preserved skeletal muscle Na<sup>+</sup>,K<sup>+</sup>‐ATPase
The Journal of Physiology·2024
Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment
Human Genomics·2024· 2 citedOpen Access
WITHDRAWN: Eligibility for thrombolysis and outcome in pediatric acute ischemic stroke
2024Open Access
Genome-wide association analysis of treatment resistant schizophrenia for variant discovery and polygenic assessment
2024Open Access
Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data
CNS Drugs·2024· 3 citedOpen Access
Shared genetic loci between clozapine metabolism and granulocyte counts
Research Square (Research Square)·2024Open Access
Effect of the <i>NFIB</i> rs28379954 <i>T</i>&gt;<i>C</i> polymorphism on <scp>CYP2D6</scp>‐catalyzed metabolism of solanidine
Clinical and Translational Science·2024· 6 citedOpen Access
Novel Identification of Cysteinyl Derivatives of Toxic Clozapine Nitrenium Ions and the Effect of Valproic Acid on Metabolite Formation: A Study Using Reprocessed High-Resolution Mass Spectra of Analyzed Therapeutic Drug Monitoring Samples
Therapeutic Drug Monitoring·2024· 8 cited
Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank study
Neuropsychopharmacology·2024· 13 citedOpen Access
Polygenic Liability for Antipsychotic Dosage and Polypharmacy - A Real-World Registry and Biobank Study
2023· 1 citedOpen Access
41766 Efficacy of a Virtual, State-Wide, Dermatology Advocacy Day in Promoting Advocacy Efforts amongst Medical Trainees
Journal of the American Academy of Dermatology·2023Open Access
Guía internacional para una dosificación más segura de la clozapina en adultos mediante el uso de 6 titulaciones personalizadas de dosis basados en la etnicidad, la proteína C reactiva y los niveles de clozapina
Psiquiatría Biológica·2023
Impact of age, sex and cytochrome P450 genotype on quetiapine and <i>N</i>‐desalkylquetiapine serum concentrations: A study based on real‐world data from 8118 patients
British Journal of Clinical Pharmacology·2023· 10 citedOpen Access
Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia
Psychiatry Research·2023· 16 citedOpen Access
Evidence for solanidine as a dietary CYP2D6 biomarker: Significant correlation with risperidone metabolism
British Journal of Clinical Pharmacology·2023· 16 citedOpen Access
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Frequent Co-authors

R. T. Williams(9), Timothy B. Adams(8), Philip S. Portoghese(8), Bernard M. Wagner(8), John Doull(7), I.C. Munro(7), P. Millburn(7), V.J. Feron(6), Jay I. Goodman(6), Lawrence J. Marnett(6), William J. Waddell(6), Colin T. Dolphin(5), John Caldwell(5), Elizabeth A. Shephard(4), Paul M. Newberne(4), Samuel M. Cohen(4), Ian Phillips(4), Adrianne E. Rogers(3), I.G. Sipes(3), S. C. Mitchell(3)