Nicholas M. Pearce

Vrije Universiteit Amsterdam — Netherlands

Materials Science · Physical Sciences

14h-index2.0kcitations63works4.02yr avg
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Research Topics

Enzyme Structure and Function(21), Protein Structure and Dynamics(19), Computational Drug Discovery Methods(8), Machine Learning in Materials Science(6), Chemical Synthesis and Analysis(5)

Publications63 total

β-Sheet mimetics that Target the Transcriptional Coactivator β-Catenin
2024Open Access
Up, up, down, down: the structural biology of the SARS-CoV-2 spike protein and how it cheats the immune system
Crystallography Reviews·2024· 8 citedOpen Access
Covalent bicyclization of protein complexes yields durable quaternary structures
Chem·2023· 14 citedOpen Access
The <i>CCP</i>4 suite: integrative software for macromolecular crystallography
Acta Crystallographica Section D Structural Biology·2023· 760 citedOpen Access
Structural biology of SARS-CoV-1/SARS-CoV-2 main protease
Crystallography Reviews·2023· 4 cited
Of problems and opportunities—How to treat and how to not treat crystallographic fragment screening data
Protein Science·2022· 13 citedOpen Access
Of Problems and Opportunities – How to Treat and How to Not Treat Crystallographic Fragment-Screening Data
2022· 4 citedOpen Access
Experiences From Developing Software for Large X-Ray Crystallography-Driven Protein-Ligand Studies
Frontiers in Molecular Biosciences·2022· 3 citedOpen Access
Mechanistic insights into the C<sub>55</sub>-P targeting lipopeptide antibiotics revealed by structure–activity studies and high-resolution crystal structures
Chemical Science·2022· 23 citedOpen Access
Improving sampling of crystallographic disorder in ensemble refinement
Acta Crystallographica Section D Structural Biology·2021· 34 citedOpen Access
Data for "Improving sampling of crystallographic disorder in Ensemble Refinement"
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
Data for "Improving sampling of crystallographic disorder in Ensemble Refinement"
2021Open Access
A method for intuitively extracting macromolecular dynamics from structural disorder
Nature Communications·2021· 34 citedOpen Access
Crystallographic approach to fragment-based hit discovery against <i>Schistosoma mansoni</i> purine nucleoside phosphorylase
Biochemical Journal·2021· 1 citedOpen Access
Refactoring the <i>B</i> factor: intuitively extracting structural dynamics from macromolecular disorder
Acta Crystallographica Section A Foundations and Advances·2021Open Access
Data for "A method for intuitively extracting macromolecular dynamics from structural disorder"
Zenodo (CERN European Organization for Nuclear Research)·2021Open Access
Data for "A method for intuitively extracting macromolecular dynamics from structural disorder"
2021Open Access
Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
Journal of Visualized Experiments·2021· 77 citedOpen Access
Rücktitelbild: Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling (Angew. Chem. 25/2021)
Angewandte Chemie·2021
Back Cover: Bicyclic β‐Sheet Mimetics that Target the Transcriptional Coactivator β‐Catenin and Inhibit Wnt Signaling (Angew. Chem. Int. Ed. 25/2021)
Angewandte Chemie International Edition·2021
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Frequent Co-authors

F. von Delft(22), T. Krojer(17), P.M. Collins(12), Charlotte M. Deane(11), R. Talon(10), J. Brandão-Neto(9), Brian D. Marsden(7), Piet Gros(7), A.R. Bradley(6), James S. Fraser(5), A. Douangamath(5), Sven Hennig(5), Tom N. Grossmann(5), Thirza van Ramshorst(4), Martin Lutz(4), Andrea Thorn(3), Sebastian Kelm(3), Jiye Shi(3), D.A. Keedy(3), Z.B. Hill(3)