Patrick Seale

University of Pennsylvania — United States

Medicine · Health Sciences

64h-index28.8kcitations169works8.92yr avg
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Research Topics

Adipose Tissue and Metabolism(84), Adipokines, Inflammation, and Metabolic Diseases(51), Lipid metabolism and biosynthesis(28), Muscle Physiology and Disorders(20), Exercise and Physiological Responses(16)

Publications169 total

EBF2 variant identified in a patient with atypical partial lipodystrophy causes adipose fibrosis and dysfunction
Journal of Clinical Investigation·2026Open Access
The innate thermogenic capacity of brown adipose tissue develops independently of sympathetic signaling
Molecular Metabolism·2025Open Access
3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility
Genome biology·2025Open Access
The transcription factor CUX1 exerts opposing roles in human and mouse adipocyte differentiation
Molecular Metabolism·2025Open Access
PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition
Nature Cardiovascular Research·2025· 4 citedOpen Access
PRDM16 controls plaque composition by modulating smooth muscle cell identity
Atherosclerosis·2025Open Access
344-OR: Understanding the Dynamic Roles of Ketone Body Metabolism of Mesenchymal Stromal Cells in the Regulation of Adipose Tissue Inflammation and Insulin Resistance
Diabetes·2025
2175-LB: Pathological Reprogramming of Adipose Tissue Mesenchymal Cells in Obesity and Metabolic Diseases
Diabetes·2025
Investigating the role of PRDM16 in enteroendocrine cell differentiation and response to nutritional change in the small intestinal epithelium
Physiology·2025
PRDM16 controls smooth muscle cell fate in atherosclerosis
2025· 2 citedOpen Access
Author response: 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
2025Open Access
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
eLife·2025· 2 citedOpen Access
Transcriptional regulation of adipocyte lipolysis by IRF2BP2
Science Advances·2025· 2 citedOpen Access
Author response: 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
2024Open Access
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
2024Open Access
miRNA and mRNA expression signatures in a HFpEF large animal model
American Journal of Physiology-Heart and Circulatory Physiology·2024
3D chromatin-based variant-to-gene maps across 57 human cell types reveal the cellular and genetic architecture of autoimmune disease susceptibility
2024· 2 citedOpen Access
Author response: 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
2024· 1 citedOpen Access
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
2024· 1 citedOpen Access
3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
eLife·2024· 3 citedOpen Access
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Frequent Co-authors

Michael A. Rudnicki(13), Bruce M. Spiegelman(12), Jeff Ishibashi(10), Shingo Kajimura(9), Hee‐Woong Lim(8), Kyoung‐Jae Won(7), Mitchell A. Lazar(6), Alexander P. Sakers(5), Wenli Yang(4), Sherry Chin(4), Matthew Harms(4), Wenshan Wang(4), Rana K. Gupta(4), Heather M. Conroe(3), Luc A. Sabourin(3), Adele Girgis-Gabardo(3), Paul Cohen(3), Rachel R. Stine(3), Atsushi Asakura(3), Mengle Shao(3)