Graham R. Cumming

Eli Lilly (Spain) — Spain

Chemistry · Physical Sciences

12h-index656citations26works4.82yr avg
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Research Topics

Asymmetric Hydrogenation and Catalysis(6), Synthesis and Catalytic Reactions(6), Innovative Microfluidic and Catalytic Techniques Innovation(5), Chemical Synthesis and Analysis(4), Synthetic Organic Chemistry Methods(4)

Publications26 total

Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754
Organic Process Research & Development·2025· 4 cited
Design of Experiments-Based Optimization of an Electrochemical Decarboxylative Alkylation Using a Spinning Cylinder Electrode Reactor
Organic Process Research & Development·2024· 7 cited
Design of Experiments-Based Optimization of an ElectrochemicalDecarboxylative Alkylation using a Spinning Cylinder ElectrodeReactor
2024· 1 citedOpen Access
Catalytic 2-Ethylhexanoic Acid Promotes Mild Miyaura Borylations
The Journal of Organic Chemistry·2024· 7 cited
Electrochemical Nickel-Catalyzed C(sp<sup>3</sup>)–C(sp<sup>3</sup>) Cross-Coupling of Alkyl Halides with Alkyl Tosylates
Journal of the American Chemical Society·2023· 57 citedOpen Access
Photochemically Mediated Ring Expansion of Indoles and Pyrroles with Chlorodiazirines: Synthetic Methodology and Thermal Hazard Assessment
Angewandte Chemie·2023· 11 citedOpen Access
Photochemically Mediated Ring Expansion of Indoles and Pyrroles with Chlorodiazirines: Synthetic Methodology and Thermal Hazard Assessment
Angewandte Chemie International Edition·2023· 74 citedOpen Access
Continuous-Flow Supercritical CO<sub>2</sub> Platform for In-Situ Synthesis and Purification of Small Molecules for Drug Discovery
Organic Process Research & Development·2023· 8 cited
Data for "Fast Continuous Alcohol Amination Employing a Hydrogen Borrowing Protocol"
Apollo (University of Cambridge)·2021Open Access
Discovery of an Orally Efficacious Positive Allosteric Modulator of the Glucagon-like Peptide-1 Receptor
Journal of Medicinal Chemistry·2021· 16 citedOpen Access
Structural insights into probe-dependent positive allosterism of the GLP-1 receptor
Nature Chemical Biology·2020· 91 cited
Fast continuous alcohol amination employing a hydrogen borrowing protocol
Green Chemistry·2018· 37 citedOpen Access
Scale-up of <i>N</i>-alkylation reaction using phase-transfer catalysis with integrated separation in flow
Reaction Chemistry & Engineering·2018· 12 cited
Investigation of the Stereoselective Synthesis of the Indane Dimer PH46A, a New Potential Anti-inflammatory Agent
Organic Process Research & Development·2017· 6 citedOpen Access
Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines
Synlett·2017· 10 citedOpen Access
Chemoselective Continuous Ru-Catalyzed Hydrogen-Transfer Oppenauer-Type Oxidation of Secondary Alcohols
Organic Process Research & Development·2017· 27 citedOpen Access
The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1<i>R</i>,2<i>S</i>)-2-(3-((<i>E</i>)-4-(((<i>cis</i>)-2,6-Dimethylmorpholino)methyl)styryl)-1<i>H</i>-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent
Journal of Medicinal Chemistry·2014· 166 citedOpen Access
Asymmetric synthesis of (+)-vertine and (+)-lythrine
Organic & Biomolecular Chemistry·2012· 18 cited
ChemInform Abstract: Total Synthesis of (.+‐.)‐Vertine (III) with Z‐Selective RCM as a Key Step.
ChemInform·2010· 1 cited
Asymmetric Catalytic Hydrogenolysis of ArylHalide Bonds in Fused Arene Chromium and Ruthenium Complexes
Chemistry - A European Journal·2010· 52 cited
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Frequent Co-authors

Pablo García‐Losada(5), Óscar de Frutos(5), Carlos Mateos(5), Ricardo Labes(4), Claudio Battilocchio(4), Juan A. Rincón(4), Steven V. Ley(4), C. Oliver Kappe(3), David Cantillo(3), E. Peter Kündig(3), María José Nieves‐Remacha(3), Laëtitia Chausset‐Boissarie(3), Roman Àrvai(3), Alan Armstrong(3), Ana B. Bueno(2), Francis S. Willard(2), David B. Wainscott(2), Aaron D. Showalter(2), Qi Chen(2), Cynthia Stutsman(2)