John D. Kulman

Medicine · Health Sciences

18h-index1.8kcitations41works0.02yr avg
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Research Topics

Hemophilia Treatment and Research(15), Platelet Disorders and Treatments(12), Blood Coagulation and Thrombosis Mechanisms(11), Coagulation, Bradykinin, Polyphosphates, and Angioedema(7), Vitamin K Research Studies(7)

Publications41 total

A versatile platform for generating engineered extracellular vesicles with defined therapeutic properties
Molecular Therapy·2021· 290 citedOpen Access
Evaluation of Homology-Independent CRISPR-Cas9 Off-Target Assessment Methods
The CRISPR Journal·2020· 48 citedOpen Access
A hetero-dimer model for concerted action of vitamin K carboxylase and vitamin K reductase in vitamin K cycle
UNC Libraries·2020· 2 citedOpen Access
BIVV001, a new class of factor VIII replacement for hemophilia A that is independent of von Willebrand factor in primates and mice
Blood·2020· 103 citedOpen Access
Abstract 2150: engEx: A novel exosome engineering platform enabling targeted transfer of pharmacological molecules
Cancer Research·2019
Abstract 2150: engEx: A novel exosome engineering platform enabling targeted transfer of pharmacological molecules
Experimental and Molecular Therapeutics·2019· 2 cited
The structural basis for the functional comparability of factor VIII and the long‐acting variant recombinant factor VIII Fc fusion protein
Journal of Thrombosis and Haemostasis·2017· 18 citedOpen Access
Glycoprotein Ib-IX-V Complex Transmits Cytoskeletal Forces That Enhance Platelet Adhesion
Biophysical Journal·2016· 65 citedOpen Access
Recombinant FVIIIFc-VWF-XTEN Demonstrates Significant Bioavailability Following Subcutaneous Administration in Hemophilia A Mice
Blood·2015· 9 cited
Prolonged Half-Life and Improved Recovery of Recombinant Factor IX-XTEN Fusion Proteins in Hemophilia B Mouse Model
Blood·2015· 3 cited
Identification of Active Coagulation Factor IX Variants with Insertion or Fusion of Unstructured Polypeptide Xten
Blood·2015
Evaluation of Enhanced in Vitro Plasma Stability of a Novel Long Acting Recombinant FVIIIFc-VWF-XTEN Fusion Protein
Blood·2015· 11 cited
Recombinant FIX/X-Bp from the Japanese Habu Snake Is a Universal Ligand for Purification of Highly Carboxylated Factor IX Variants and Factor X
Blood·2015
Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry
Blood·2015· 67 citedOpen Access
Enhanced Pharmacokinetics of Factor VIIa as a Monomeric Fc Fusion
Thrombosis Research·2015· 21 cited
Assessing Structure-Activity Relationships in FVIII By Integration of Structural, Biophysical, and Biochemical Data Obtained with Anti-FVIII Antibodies
Blood·2014· 1 cited
A Single Chain Variant of Factor VIII Fc Fusion Protein Retains Normal In Vivo Efficacy but Exhibits Altered In Vitro Activity
PLoS ONE·2014· 12 citedOpen Access
Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex
Blood·2014· 111 citedOpen Access
A cellular system for quantitation of vitamin K cycle activity: structure-activity effects on vitamin K antagonism by warfarin metabolites
Blood·2013· 40 citedOpen Access
Evidence For Flexible Tethering Of Fc To FVIII In Recombinant FVIII-Fc Fusion Protein rFVIIIFc
Blood·2013
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Frequent Co-authors

Robert Peters(14), Earl W. Davie(8), J. Harris(6), Qi Lü(5), Tongyao Liu(5), Allison Goodman(5), Volker Schellenberger(5), Glenn F. Pierce(4), Ekta Seth Chhabra(4), Amy M. Holthaus(4), Ayman Ismail(4), Po‐Lin Chiu(4), George M. Bou-Assaf(4), Thomas Walz(4), Adam D. Munday(4), Russell E. McConnell(3), Nuruddeen D. Lewis(3), Sonya Haupt(3), Shelly Martin(3), Chang Ling Sia(3)