Anna Borodovsky

Alnylam Pharmaceuticals (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index10.5kcitations66works20.02yr avg
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Research Topics

RNA Interference and Gene Delivery(15), Complement system in diseases(12), Ubiquitin and proteasome pathways(11), Advanced biosensing and bioanalysis techniques(8), Peptidase Inhibition and Analysis(6)

Publications66 total

Rare predicted loss-of-function and damaging missense variants in CFHR5 associate with protection from age-related macular degeneration
The American Journal of Human Genetics·2025· 1 citedOpen Access
Rare predicted loss-of-function and damaging missense variants in <i>CFHR5</i> associate with protection from age-related macular degeneration
2024· 1 citedOpen Access
Phase 2 Trial of Cemdisiran in Adult Patients with IgA Nephropathy: A Randomized Controlled Trial
Clinical Journal of the American Society of Nephrology·2024· 58 citedOpen Access
Results of a phase 1/2 study of cemdisiran in healthy subjects and patients with paroxysmal nocturnal hemoglobinuria
eJHaem·2023· 16 citedOpen Access
830-P: Preclinical Development of ALN-KHK, an Investigational RNAi Therapeutic for Type 2 Diabetes Mellitus
Diabetes·2023· 1 cited
The classical pathway triggers pathogenic complement activation in membranous nephropathy
Nature Communications·2023· 84 citedOpen Access
Pharmacokinetics and pharmacodynamics of pozelimab alone or in combination with cemdisiran in non-human primates
PLoS ONE·2022· 20 citedOpen Access
Correction to: Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria
Clinical Pharmacokinetics·2022Open Access
A bioassay for neuromuscular junction-restricted complement activation by myasthenia gravis acetylcholine receptor antibodies
Journal of Neuroscience Methods·2022· 17 citedOpen Access
The Classical Pathway Triggers Pathogenic Complement Activation in Membranous Nephropathy
Journal of the American Society of Nephrology·2021
Renal Injury Biomarkers Are Elevated in Acute Hepatic Porphyria
Journal of the American Society of Nephrology·2021
Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria
Clinical Pharmacokinetics·2020· 73 citedOpen Access
Knockdown of liver-derived factor XII by GalNAc-siRNA ALN-F12 prevents thrombosis in mice without impacting hemostatic function
Thrombosis Research·2020· 21 citedOpen Access
Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D
Frontiers in Immunology·2020· 13 citedOpen Access
Investigational RNAi Therapeutic Targeting C5 Is Efficacious in Pre-clinical Models of Myasthenia Gravis
Molecular Therapy — Methods & Clinical Development·2019· 52 citedOpen Access
Publisher Correction: ApoE attenuates unresolvable inflammation by complex formation with activated C1q
Nature Medicine·2019· 5 citedOpen Access
ApoE attenuates unresolvable inflammation by complex formation with activated C1q
Nature Medicine·2019· 300 citedOpen Access
Development of Liver-Specific Thrombopoietin Targeted Sirnas: Impact on Platelet Count, Megakaryocyte Mass, and Hematopoietic Progenitors in Normal and MPN Murine Models
Blood·2018· 2 cited
An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema
RNA·2018· 42 citedOpen Access
Effects on arthritis of RNAi-mediated targeting of liver expression of mannan-binding lectin associated serine protease 1 and 2
Molecular Immunology·2018
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Frequent Co-authors

Kevin Fitzgerald(17), Daniel G. Anderson(11), Matthias Nahrendorf(11), Ralph Weissleder(10), Filip K. Świrski(10), Hidde L. Ploegh(9), Yoshiko Iwamoto(9), Benedikt M. Kessler(8), Gabriel Courties(8), Peter Libby(8), Martin A. Maier(7), Partha Dutta(7), Kristina Yucius(7), William Querbes(6), Akin Akinc(6), Muthiah Manoharan(6), Klaus Charissé(6), Hendrik B. Sager(6), Timo Heidt(6), Gregory R. Wojtkiewicz(6)