E. B. Sirota

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Materials Science · Physical Sciences

43h-index7.1kcitations149works2.12yr avg
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Research Topics

Material Dynamics and Properties(33), Liquid Crystal Research Advancements(24), nanoparticles nucleation surface interactions(24), Surfactants and Colloidal Systems(23), Crystallization and Solubility Studies(21)

Publications149 total

Leveraging Reactive Crystal Spherical Agglomeration to Enable a Scalable and Gelation-Free Manufacturing Process for Medium-Length Fatty Acid Sodium Salts
Crystal Growth & Design·2025
Biocatalytic Aerobic Oxidation for Large-Scale Production of <i>trans</i>-3-Hydroxy-<scp>l</scp>-Proline
Organic Process Research & Development·2025· 2 cited
Attribute ranging as a coordinated strategy between drug substance and drug product to accelerate commercial process nomination
Journal of Pharmaceutical Sciences·2024
Spontaneous assembly of condensate networks during the demixing of structured fluids
arXiv (Cornell University)·2024Open Access
Concomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization. Part 1: Theoretical Basis and Workflow for Efficient Impurity Rejection
Organic Process Research & Development·2024· 7 cited
CCDC 2224106: Experimental Crystal Structure Determination
The Cambridge Structural Database·2024Open Access
Concomitant Precipitation of Solid-State Miscible Product-Impurity Phases in Solution Crystallization – Part 2: Industrial Case Studies
Organic Process Research & Development·2024· 6 cited
Manufacturing Process Development for the Biaryl Ether Fragment of Nemtabrutinib (MK-1026)
Organic Process Research & Development·2023· 3 cited
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19
Organic Process Research & Development·2023· 5 cited
New Bench-Scale Method To Elucidate Active Pharmaceutical Ingredient Drying Mechanisms
Organic Process Research & Development·2023· 1 cited
Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations
Organic Process Research & Development·2023· 37 citedOpen Access
Leveraging Synergistic Solubility in the Development of a Direct Isolation Process for Nemtabrutinib
Organic Process Research & Development·2023· 8 cited
Method to Rapidly Identify Potential Solvent Systems for Crystallization of Cocrystals
Organic Process Research & Development·2023· 7 cited
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19
Organic Process Research & Development·2021· 35 cited
Manufacturing Process Development for Belzutifan, Part 5: A Streamlined Fluorination–Dynamic Kinetic Resolution Process
Organic Process Research & Development·2021· 42 cited
Cross-Pharma Collaboration for the Development of a Simulation Tool for the Model-Based Digital Design of Pharmaceutical Crystallization Processes (CrySiV)
Crystal Growth & Design·2021· 19 cited
Development of an Efficient Route to 2-Ethynylglycerol for the Synthesis of Islatravir
2021· 4 citedOpen Access
Development of an Efficient Route to 2-Ethynylglycerol for the Synthesis of Islatravir
2021· 2 citedOpen Access
Development and Demonstration of a Co-feed Process to Address Form and Physical Attribute Control of the Gefapixant (MK-7264) Citrate Active Pharmaceutical Ingredient
Organic Process Research & Development·2021· 1 cited
Crystallization Process Development for the Final Step of the Biocatalytic Synthesis of Islatravir: Comprehensive Crystal Engineering for a Low-Dose Drug
Organic Process Research & Development·2021· 13 cited
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Frequent Co-authors

Moshe Deutsch(12), B. M. Ocko(11), Xian Wu(10), Cyrus R. Safinya(6), Oleg Gang(6), Noel A. Clark(4), H. E. King(4), D. Singer(4), Robert J. Plano(4), L. B. Sorensen(4), Gregory S. Smith(3), Henry H. Shao(3), Amy B. Herhold(3), Gianfranco Mazzanti(3), Sarah Guthrie(3), Alejandro G. Marangoni(3), Stefan H. J. Idziak(3), Srivatsan Srinivas(3), H. Kraack(3), P. S. Pershan(3)