Yasuhiro Uno

Kagoshima University — Japan

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

29h-index3.0kcitations211works2.82yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(163), Drug Transport and Resistance Mechanisms(126), Drug-Induced Hepatotoxicity and Protection(35), Pharmacological Effects and Toxicity Studies(29), Eicosanoids and Hypertension Pharmacology(26)

Publications211 total

Genetic variants of flavin-containing monooxygenase (FMO) 1 and FMO3 in 5887 dogs influenced oxygenations of probe substrates benzydamine, trimethylamine, and methyl p-tolyl sulfide
Biochemical Pharmacology·2026
Novel cytochrome P450 2J isoforms in tree shrews are functional drug-metabolising enzymes involved in ebastine and astemizole oxidation
Xenobiotica·2026
Genetic variants in dog cytochrome P450 2B6 and their relevance to interindividual variability of oxidations of probe drug propofol
Drug Metabolism and Disposition·2025
Genetic variants of cytochrome P450 2C21 identified by screening 6344 dogs influenced oxidations of the probe drug omeprazole
Biochemical Pharmacology·2025
Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs
Drug Metabolism and Disposition·2025· 2 cited
Investigation of genetic polymorphisms in pig cytochromes P450 1A2, 2A19, 2C33, 2D25, and 3A22 to elucidate inter-individual variability of hepatic drug oxidations
Biochemical Pharmacology·2025· 1 cited
Exploration of functional cytochrome P450 4F enzymes in liver, intestine, and kidney from dogs, cats, pigs, and tree shrews and comparison of their metabolic capacities with human P450 4F2 and 4F12
Biochemical Pharmacology·2025· 2 cited
Novel dog hepatic cytochrome P450 3A293 oxidizes endogenous testosterone and estradiol
Biochemical Pharmacology·2025· 2 cited
Investigation of Functional Cytochrome P450 4A Enzymes in Liver and Kidney of Pigs, Cats, Tree Shrews, and Dogs in Comparison with the Metabolic Capacity of Human P450 4A11
Drug Metabolism and Disposition·2024· 2 cited
Quinuclidine N-Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs
Drug Metabolism and Disposition·2024· 4 citedOpen Access
A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models
Biochemical Pharmacology·2024· 10 cited
Transcript abundance of hepatic drug-metabolizing enzymes in two dog breeds compared with 14 species including humans
Drug Metabolism and Pharmacokinetics·2024· 3 cited
Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan
Drug Metabolism and Disposition·2024· 7 cited
Molecular and functional characterization of flavin-containing monooxygenases (FMO1–6) in tree shrews
Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology·2024· 5 cited
Habu snakes (<i>Protobothrops flavoviridis</i>) show variation in thoracic aortic vasoreactivity between adjacent Japanese islands
Journal of Veterinary Medical Science·2023Open Access
Identification of cytochrome P450 2C18 and 2C76 in tree shrews: P450 2C18 effectively oxidizes typical human P450 2C9/2C19 chiral substrates warfarin and omeprazole with less stereoselectivity
Biochemical Pharmacology·2023· 4 cited
Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole
Drug Metabolism and Disposition·2023· 5 cited
Characterization of Vasoreactivity in a Semi-Arboreal Snake, the Tokara Habu (Protobothrops tokarensis)
Animals·2023· 2 citedOpen Access
Chronic <i>Toxoplasma</i> infection affects gene expression of drug-metabolizing enzymes in mouse liver
Xenobiotica·2023
Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and <i>p</i> -nitrophenol
Xenobiotica·2023· 3 cited
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Frequent Co-authors

Hiroshi Yamazaki(38), Shotaro Uehara(22), Norie Murayama(18), Makiko Shimizu(17), Masahiro Utoh(16), Kazuhide Iwasaki(11), Erika Sasaki(10), Takashi Inoue(9), Ryoichi Nagata(6), Hideki Fujino(5), Go Kito(5), Tetsuya Kamataki(5), Chika Nakamura(4), Naoki Osada(4), Shinya Hosaka(3), Kiyomi Matsuno(3), Akinori Matsushita(3), Sakae Kohara(3), Yasuharu Nakanishi(3), Akiko Toda(3)