David W. Emery

University of Washington — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index2.0kcitations77works0.02yr avg
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Research Topics

Virus-based gene therapy research(46), CRISPR and Genetic Engineering(30), RNA Interference and Gene Delivery(18), Viral Infectious Diseases and Gene Expression in Insects(9), Xenotransplantation and immune response(9)

Publications77 total

Investigating the Barrier Activity of Novel, Human Enhancer-Blocking Chromatin Insulators for Hematopoietic Stem Cell Gene Therapy
Human Gene Therapy·2021· 7 citedOpen Access
Supplementary Material for: The cHS4 Chromatin Insulator Reduces the Rate of Retroviral Vector-Mediated Gene Dysregulation Associated with Aberrant Vector Transcription
Figshare·2017Open Access
The cHS4 Chromatin Insulator Reduces the Rate of Retroviral Vector-Mediated Gene Dysregulation Associated with Aberrant Vector Transcription
Cytogenetic and Genome Research·2017· 3 cited
Supplementary Material for: The cHS4 Chromatin Insulator Reduces the Rate of Retroviral Vector-Mediated Gene Dysregulation Associated with Aberrant Vector Transcription
Figshare·2017Open Access
Rethinking the Regulatory Infrastructure for Human Gene Transfer Clinical Trials
Molecular Therapy·2016· 1 citedOpen Access
656. Small Molecule Induced Robust Erythroid Differentiation of Cord Blood CD34+ Cells Mimics the Central Macrophage Milieu in Erythroblastic Islands
Molecular Therapy·2015Open Access
Functional Validation of a Constitutive Autonomous Silencer Element
PLoS ONE·2015· 25 citedOpen Access
Genomic discovery of potent chromatin insulators for human gene therapy
Nature Biotechnology·2015· 130 cited
A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor
Blood·2014· 15 citedOpen Access
Big Changes Coming To Biosafety Oversight of Clinical Gene Transfer
Molecular Therapy·2014· 1 citedOpen Access
Identification and Characterization of Enhancer-Blocking Insulators to Reduce Retroviral Vector Genotoxicity
PLoS ONE·2013· 16 citedOpen Access
Corrigendum to “Long-term Regulation of Genetically Modified Primary Hematopoietic Cells in Dogs”
Molecular Therapy·2011Open Access
Gammaretroviral Vector Integration Occurs Overwhelmingly Within and Near DNase Hypersensitive Sites
Human Gene Therapy·2011· 6 citedOpen Access
Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo
Blood Cells Molecules and Diseases·2011· 16 citedOpen Access
Long-term Regulation of Genetically Modified Primary Hematopoietic Cells in Dogs
Molecular Therapy·2011· 15 citedOpen Access
The Use of Chromatin Insulators to Improve the Expression and Safety of Integrating Gene Transfer Vectors
Human Gene Therapy·2011· 91 cited
Gene therapy for β-thalassaemia: the continuing challenge
Expert Reviews in Molecular Medicine·2010· 21 cited
Poly(ADP-ribose) Polymerase-1 (PARP-1) Contributes to the Barrier Function of a Vertebrate Chromatin Insulator
Journal of Biological Chemistry·2010· 11 citedOpen Access
A functional screen for regulatory elements that improve retroviral vector gene expression
Blood Cells Molecules and Diseases·2010· 1 citedOpen Access
Genomic and Functional Assays Demonstrate Reduced Gammaretroviral Vector Genotoxicity Associated With Use of the cHS4 Chromatin Insulator
Molecular Therapy·2009· 63 citedOpen Access
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Frequent Co-authors

George Stamatoyannopoulos(20), David H. Sachs(10), Julie Tubb(9), Tomasz Sablinski(6), Christian LeGuern(6), Evangelia Yannaki(5), Tamon Nishino(5), C. Anthony Blau(5), Mari Aker(5), Qiliang Li(4), Sharon Germana(4), John W. Rooney(4), Mingdong Liu(3), Amy C. Groth(3), Pierre Gianello(3), Thomas Lorf(3), Hideaki Shimada(3), J. Scott Arn(3), Megan Sykes(3), Carol Hopkins Sibley(3)