Alfred H. Schinkel

Oncode Institute — Netherlands

Medicine · Health Sciences

95h-index38.4kcitations432works2.72yr avg
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Research Topics

Drug Transport and Resistance Mechanisms(272), Pharmacological Effects and Toxicity Studies(115), Pharmacogenetics and Drug Metabolism(72), Cancer therapeutics and mechanisms(46), Acute Lymphoblastic Leukemia research(37)

Publications432 total

Resistance mutations and the blood–brain barrier: Key challenges in targeted treatment of brain metastatic non-small cell lung cancer
Acta Pharmaceutica Sinica B·2025· 3 citedOpen Access
Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice
Acta Pharmacologica Sinica·2024· 5 citedOpen Access
Brain Exposure to the Macrocyclic ALK Inhibitor Zotizalkib is Restricted by ABCB1, and Its Plasma Disposition is Affected by Mouse Carboxylesterase 1c
Molecular Pharmaceutics·2024· 1 cited
TRSC-06 CHARACTERIZATION OF A NON-SMALL CELL LUNG CANCER ROS1-FUSION BRAIN METASTASIS MODEL
Neuro-Oncology Advances·2024Open Access
The role of drug efflux and uptake transporters in the plasma pharmacokinetics and tissue disposition of morphine and its main metabolites
Toxicology and Applied Pharmacology·2024· 2 cited
ABCB1 attenuates brain exposure to the KRASG12C inhibitor opnurasib whereas binding to mouse carboxylesterase 1c influences its plasma exposure
Biomedicine & Pharmacotherapy·2024· 7 citedOpen Access
Interplay of OATP1A/1B/2B1 uptake transporters and ABCB1 and ABCG2 efflux transporters in the handling of bilirubin and drugs
Biomedicine & Pharmacotherapy·2024· 2 citedOpen Access
The ABCB1 and ABCG2 efflux transporters limit brain disposition of the SYK inhibitors entospletinib and lanraplenib
Toxicology and Applied Pharmacology·2024· 5 cited
Impact of loperamide on the pharmacokinetics and tissue disposition of ritonavir-boosted oral docetaxel therapy; a preclinical assessment
Cancer Chemotherapy and Pharmacology·2024
Interplay of Ritonavir-Boosted Oral Cabazitaxel with the Organic Anion-Transporting Polypeptide (OATP) Uptake Transporters and Carboxylesterase 1 in Mice
Molecular Pharmaceutics·2024· 2 cited
Coadministration of ABCB1/P-glycoprotein inhibitor elacridar improves tissue distribution of ritonavir-boosted oral cabazitaxel in mice
International Journal of Pharmaceutics·2023· 3 cited
Development and validation of an LC-MS/MS method for the quantification of KRASG12C inhibitor opnurasib in several mouse matrices and its application in a pharmacokinetic mouse study
Journal of Chromatography B·2023· 2 citedOpen Access
Predictability of human exposure by human‐CYP3A4‐transgenic mouse models: A meta‐analysis
Clinical and Translational Science·2023· 2 citedOpen Access
Development and validation of an HPLC–MS/MS method to quantify the KRAS inhibitor adagrasib in mouse plasma and tissue‐related matrices
Biomedical Chromatography·2023· 6 citedOpen Access
Pharmacokinetics of the KRASG12C inhibitor adagrasib is limited by CYP3A and ABCB1, and influenced by binding to mouse plasma carboxylesterase 1c
Biomedicine & Pharmacotherapy·2023· 10 citedOpen Access
Validated LC-MS/MS method for simultaneous quantification of KRASG12C inhibitor sotorasib and its major circulating metabolite (M24) in mouse matrices and its application in a mouse pharmacokinetic study
Journal of Pharmaceutical and Biomedical Analysis·2023· 4 citedOpen Access
P-glycoprotein (MDR1/ABCB1) Restricts Brain Penetration of the Main Active Heroin Metabolites 6-monoacetylmorphine (6-MAM) and Morphine in Mice
Pharmaceutical Research·2023· 5 cited
Natural deletion of mouse carboxylesterases Ces1c/d/e impacts drug metabolism and metabolic syndrome development
Biomedicine & Pharmacotherapy·2023· 10 citedOpen Access
Supplementary Figures 1 through 3 and Supplementary Tables 1 through 3 from OATP1A/1B Transporters Affect Irinotecan and SN-38 Pharmacokinetics and Carboxylesterase Expression in Knockout and Humanized Transgenic Mice
2023Open Access
Supplementary Figures 1 through 3 and Supplementary Tables 1 through 3 from OATP1A/1B Transporters Affect Irinotecan and SN-38 Pharmacokinetics and Carboxylesterase Expression in Knockout and Humanized Transgenic Mice
2023Open Access
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Frequent Co-authors

Els Wagenaar(19), Piet Borst(15), Johan W. Jonker(12), Olaf van Tellingen(10), Jos H. Beijnen(10), Liesbeth van Deemter(9), Carla A.A.M. Mol(8), Ronald P.J. Oude Elferink(7), Jan H.M. Schellens(6), Antonius E. van Herwaarden(6), Martin A. van der Valk(5), Johan W. Smit(5), Gracia Merino(5), Jasper Smit(4), John Allen(4), Maarten T. Huisman(4), George L. Scheffer(3), Alex Sparreboom(3), Hilde Rosing(3), Jan Wijnholds(3)