Giacomo Masserdotti

Helmholtz Zentrum München — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index3.4kcitations39works8.52yr avg
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Research Topics

Pluripotent Stem Cells Research(16), Neurogenesis and neuroplasticity mechanisms(15), CRISPR and Genetic Engineering(8), 3D Printing in Biomedical Research(8), Neuroscience and Neural Engineering(8)

Publications39 total

Fibrin-containing Hydrogels Regulate Human Astrocyte State and Neuronal Reprogramming
2025Open Access
Fibrin-containing Hydrogels Regulate Human Astrocyte State and Neuronal Reprogramming
2025
Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner
Genome biology·2025· 2 citedOpen Access
Single Cell Deletion of the Transcription Factors Trps1 and Sox9 in Astrocytes Reveals Novel Functions in the Adult Cerebral Cortex
Glia·2024· 7 citedOpen Access
Late onset Alzheimer’s disease: modeling disease hallmarks via in vitro 3D iNeuron cultures
Signal Transduction and Targeted Therapy·2024· 1 citedOpen Access
Comparing Viral Vectors and Fate Mapping Approaches for Astrocyte-to-Neuron Reprogramming in the Injured Mouse Cerebral Cortex
Cells·2024· 9 citedOpen Access
Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1
Nature Neuroscience·2024· 35 citedOpen Access
Direct neuronal reprogramming of NDUFS4 patient cells identifies the unfolded protein response as a novel general reprogramming hurdle
Neuron·2024· 14 citedOpen Access
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
Nature Medicine·2023· 39 citedOpen Access
Hmgb2 improves astrocyte to neuron conversion by increasing the chromatin accessibility of genes associated with neuronal maturation in a proneuronal factor-dependent manner
2023· 1 citedOpen Access
Primary Aldosteronism: Spatial Multiomics Mapping of Genotype-Dependent Heterogeneity and Tumor Expansion of Aldosterone-Producing Adenomas
Hypertension·2023· 18 citedOpen Access
Probing cell identity hierarchies by fate titration and collision during direct reprogramming
Molecular Systems Biology·2022· 26 citedOpen Access
Isolation and Direct Neuronal Reprogramming of Mouse Astrocytes
Journal of Visualized Experiments·2022· 1 cited
Isolation and Direct Neuronal Reprogramming of Mouse Astrocytes
Journal of Visualized Experiments·2022· 1 cited
Parkinson's disease motor symptoms rescue by CRISPRa‐reprogramming astrocytes into GABAergic neurons
EMBO Molecular Medicine·2022· 74 citedOpen Access
Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches
Neuron·2021· 123 citedOpen Access
Heterogeneity of neurons reprogrammed from spinal cord astrocytes by the proneural factors Ascl1 and Neurogenin2
Cell Reports·2021· 43 citedOpen Access
CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion
Cell stem cell·2021· 17 citedOpen Access
CRISPR-Mediated Induction of Neuron-Enriched Mitochondrial Proteins Boosts Direct Glia-to-Neuron Conversion
Cell stem cell·2020· 69 citedOpen Access
A decade of questions about the fluidity of cell identity
Nature·2020· 3 citedOpen Access
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Frequent Co-authors

Magdalena Götz(25), Benedikt Berninger(10), Sergio Gascón(8), Jovica Ninkovic(6), Christophe Heinrich(5), D. Chichung Lie(5), Stefanie M. Hauck(5), Bob A. Hersbach(5), Tatiana Simon(5), Rodrigo Sánchez(4), Timm Schroeder(4), Felipe Ortega(4), Gianluca Luigi Russo(4), Judith Fischer(4), Riccardo Bocchi(4), Laura Croci(4), G. Giacomo Consalez(4), Giovanna Sonsalla(4), Juliane Merl‐Pham(4), David Petřík(3)