Sascha Rutz

Kaiser Permanente South San Francisco Medical Center — United States

Medicine · Health Sciences

34h-index7.7kcitations87works1.62yr avg
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Research Topics

CAR-T cell therapy research(33), Cancer Immunotherapy and Biomarkers(23), Immune Cell Function and Interaction(23), Immunotherapy and Immune Responses(19), T-cell and B-cell Immunology(16)

Publications87 total

Pseudokinase STK40 limits T cell exhaustion through COP1-dependent degradation of AP1-family transcription factors
Nature Immunology·2025
QSP model trained on preclinical data informs clinical dose selection for a T-cell engaging bispecific antibody for solid tumor indications
2025
385 Identification of TCRs targeting shared tumor antigens
Regular and Young Investigator Award Abstracts·2024Open Access
334 Computational mapping of CAR-T cell exhaustion through single-cell perturbation screens
Regular and Young Investigator Award Abstracts·2024Open Access
282 Improving solid tumor CAR-T therapies by modulating T cell transcriptional states using combinatorial <i>in vitro</i> CRISPR screening followed by <i>in vivo</i> validation
Regular and Young Investigator Award Abstracts·2024Open Access
A real-time antibody-dependent cellular phagocytosis assay by live cell imaging
Journal of Immunological Methods·2024· 4 cited
Optimization of a Novel DEL Hit That Binds in the Cbl-b SH2 Domain and Blocks Substrate Binding
ACS Medicinal Chemistry Letters·2024· 8 citedOpen Access
Author Correction: c-Maf-dependent Treg cell control of intestinal TH17 cells and IgA establishes host–microbiota homeostasis
Nature Immunology·2024· 1 citedOpen Access
An image-based real time method to measure antibody-dependent cellular phagocytosis
The Journal of Immunology·2024Open Access
Abstract 7042: Enhancing TCR T cell function in solid tumors through <i>in vivo</i> combinatorial screens and single-cell analysis
Cancer Research·2024
Abstract 2059: An image-based real time method to measure antibody-dependent cellular phagocytosis
Cancer Research·2024
Abstract 7034: Pooled CRISPR screening coupled with single-cell sequencing identifies modifiers of CAR T cell state in the context of chronic antigen stimulation
Cancer Research·2024
Preclinical and translational pharmacology of afucosylated anti‐CCR8 antibody for depletion of tumour‐infiltrating regulatory T cells
British Journal of Pharmacology·2024· 8 citedOpen Access
Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8
Nature Communications·2023· 24 citedOpen Access
Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity
Cell Reports·2023· 3 citedOpen Access
Data from Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8&lt;sup&gt;+&lt;/sup&gt; T Cells in Murine Syngeneic Tumor Models
2023Open Access
Movie S1 Legend from Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8&lt;sup&gt;+&lt;/sup&gt; T Cells in Murine Syngeneic Tumor Models
2023Open Access
Movie S1 Legend from Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8&lt;sup&gt;+&lt;/sup&gt; T Cells in Murine Syngeneic Tumor Models
2023Open Access
Movie S1 from Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8&lt;sup&gt;+&lt;/sup&gt; T Cells in Murine Syngeneic Tumor Models
2023Open Access
Database of flow cytometry parameters in tumor models from Coexpression of Inhibitory Receptors Enriches for Activated and Functional CD8&lt;sup&gt;+&lt;/sup&gt; T Cells in Murine Syngeneic Tumor Models
2023Open Access
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Frequent Co-authors

Wenjun Ouyang(15), Alexander Scheffold(12), Céline Eidenschenk(12), Wolfram Sterry(8), Zora Modrušan(7), Sylke Gellrich(7), Teresita L. Arenzana(6), Sven Golembowski(6), Akiko Seki(5), Jason A. Hackney(5), Heike Audring(5), Sigbert Jahn(5), James T. Koerber(5), Ira Mellman(4), Xiaoting Wang(4), Rajkumar Noubade(4), Christian Neumann(4), Marko Janke(4), Pamela Lorenz(4), Soyoung Oh(3)