Kevin Blighe

Bioinformatics Institute — Singapore

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index2.3kcitations87works0.22yr avg
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Research Topics

Cancer Genomics and Diagnostics(13), Single-cell and spatial transcriptomics(8), Genetic factors in colorectal cancer(8), Monoclonal and Polyclonal Antibodies Research(7), Rheumatoid Arthritis Research and Therapies(6)

Publications87 total

A novel potent and selective GCN2 inhibitor, APL-4098, has anti-leukemic activity through dysregulation of mitochondrial function
Clinical Cancer Research·2026Open Access
Warp Speed Ahead! - Traveling Faster Than Light
Zenodo (CERN European Organization for Nuclear Research)·2026Open Access
Warp Speed Ahead! - Traveling Faster Than Light
Zenodo (CERN European Organization for Nuclear Research)·2026Open Access
Warp Speed Ahead! - Traveling Faster Than Light
Zenodo (CERN European Organization for Nuclear Research)·2026Open Access
The distortion of biological truth: A critical examination of UMAP in single-cell RNA-seq analysis
Zenodo (CERN European Organization for Nuclear Research)·2026Open Access
The Algorithmic Eureka: Transcending Biological Limitations to Achieve Synthetic Inference and Critical Thought
Zenodo (CERN European Organization for Nuclear Research)·2026Open Access
The distortion of biological truth: A critical examination of UMAP in single-cell RNA-seq analysis
Zenodo (CERN European Organization for Nuclear Research)·2026Open Access
The Algorithmic Eureka: Transcending Biological Limitations to Achieve Synthetic Inference and Critical Thought
Zenodo (CERN European Organization for Nuclear Research)·2026Open Access
The distortion of biological truth: A critical examination of UMAP in single-cell RNA-seq analysis
Zenodo (CERN European Organization for Nuclear Research)·2026Open Access
Nonclinical evaluation of APL-4098, a novel GCN2 kinase inhibitor, reveals potent anti-leukemic effects through mitochondrial stress induction and synergy with venetoclax, targeting AML blasts and LSCs
Blood·2025
An ISR-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation
Life Science Alliance·2025· 2 citedOpen Access
An integrated stress response-independent role of GCN2 prevents excessive ribosome biogenesis and mRNA translation
2024Open Access
Abstract 450: GCN2 protects cancer cells from hypertranslation and metabolic crisis
Cancer Research·2024
Global Ring Study to Investigate the Comparability of Total Assay Performance of Commercial Claudin 18 Antibodies for Evaluation in Gastric Cancer
Laboratory Investigation·2023· 19 citedOpen Access
Transcription factor combinations that define human astrocyte identity encode significant variation of maturity and function
Glia·2023· 9 citedOpen Access
High-throughput sequencing of IgH gene in minor salivary glands from Sjögren's syndrome patients reveals dynamic B cell recirculation between ectopic lymphoid structures
Clinical and Experimental Rheumatology·2022· 4 citedOpen Access
IgG antibody production and persistence to 6 months following SARS-CoV-2 vaccination: A Northern Ireland observational study
Vaccine·2022· 13 citedOpen Access
Development and validation of resource-driven risk prediction models for incident chronic kidney disease in type 2 diabetes
Scientific Reports·2021· 9 citedOpen Access
Large contribution of copy number alterations in early stage of Papillary Thyroid Carcinoma
Computers in Biology and Medicine·2021· 5 cited
Evaluation of the IgG antibody response to SARS CoV-2 infection and performance of a lateral flow immunoassay: cross-sectional and longitudinal analysis over 11 months
BMJ Open·2021· 25 citedOpen Access
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Frequent Co-authors

Justin Stebbing(11), Tara Moore(10), Jacqui Shaw(8), M. Andrew Nesbit(8), David S. Guttery(7), R. Charles Coombes(7), Karen Page(6), Rachel S. Kelly(6), Bo Chawes(6), Jessica Lasky‐Su(6), James McLaughlin(6), Scott T. Weiss(5), Agnes Awuah(5), Shahram Kordasti(5), Costantino Pitzalis(4), Louise J. Robertson(4), Connie Chao-Shern(4), Julie Moore(4), Luqman Bin Safdar(4), Stefano Bombardieri(3)