Samra Obeid

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index468citations24works0.02yr avg
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Research Topics

DNA and Nucleic Acid Chemistry(15), DNA Repair Mechanisms(6), Advanced biosensing and bioanalysis techniques(4), Electron Spin Resonance Studies(3), Protein Structure and Dynamics(2)

Publications24 total

DNA polymerases in action with modified substrates
2014
Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides
Journal of the American Chemical Society·2013· 26 cited
Amino Acid Templating Mechanisms in Selection of Nucleotides Opposite Abasic Sites by a Family A DNA Polymerase
Journal of Biological Chemistry·2012· 27 citedOpen Access
Ternary Structure of the large Fragment of Taq DNA polymerase
2012
Ternary Structure of the large Fragment of Taq DNA Polymerase: 4-Fluoroproline Variant
2012
Interactions of non-polar and “Click-able” nucleotides in the confines of a DNA polymerase active site
Chemical Communications·2012· 31 cited
Structural insights into the potential of 4-fluoroproline to modulate biophysical properties of proteins
Chemical Science·2012· 41 cited
Snapshots of DNA polymerase processing aberrant substrates : Structural insights into abasic site bypass and polymerization of 5-alkynylated nucleotide analogs
KOPS (University of Konstanz)·2012
Cover Picture: Learning from Directed Evolution: <i>Thermus aquaticus</i> DNA Polymerase Mutants with Translesion Synthesis Activity (ChemBioChem 10/2011)
ChemBioChem·2011Open Access
Ternary Structure of the large fragment of Taq DNA polymerase bound to an abasic site and a ddGTP
2011
Binary Structure of the large fragment of Taq DNA polymerase bound to an abasic site
2011
Learning from Directed Evolution: <i>Thermus aquaticus</i> DNA Polymerase Mutants with Translesion Synthesis Activity
ChemBioChem·2011· 23 cited
Lost in replication: DNA polymerases encountering non-instructive DNA lesions
2011
Structural basis for the synthesis of nucleobase modified DNA by <i>Thermus aquaticus</i> DNA polymerase
Proceedings of the National Academy of Sciences·2010· 82 citedOpen Access
Structure of a mutant of the large fragment of DNA polymerase I from Thermus Auqaticus in complex with an abasic site and ddATP
2010
Snapshots of the large fragment of DNA polymerase I from Thermus Aquaticus processing C5 modified thymidines
2010
Replication through an abasic DNA lesion: structural basis for adenine selectivity
The EMBO Journal·2010· 92 citedOpen Access
Structure of Klenow fragment of Taq polymerase in complex with an abasic site
2010
Enzymatic Synthesis of multi Spin-labeled DNA
Nucleic Acids Symposium Series·2008· 2 citedOpen Access
Enzymatische Synthese mehrfach spinmarkierter DNA
Angewandte Chemie·2008· 37 cited
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Frequent Co-authors

Kay Diederichs(15), Andreas Marx(13), Wolfram Welte(7), Ailie Marx(6), Nina Blatter(4), Andreas Schnur(3), Maxim Yulikov(3), Gunnar Jeschke(3), Bastian Holzberger(3), Holger Bußkamp(3), W. Welte(2), Christian Johannes Gloeckner(2), Viktor O. Iaroshenko(2), Ulrich Groth(2), Nadiya Kryvokhyzha(2), Andrei A. Tolmachev(2), Thomas Wesch(2), Ramon Kranaster(1), Anna Baccaro(1), K. Bergen(1)