Larissa Savelyeva

German Cancer Research Center — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index2.5kcitations62works0.02yr avg
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Research Topics

Genomic variations and chromosomal abnormalities(24), Neuroblastoma Research and Treatments(20), Genetics and Neurodevelopmental Disorders(17), DNA Repair Mechanisms(13), Virus-based gene therapy research(8)

Publications62 total

Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome
Nature Communications·2021· 101 citedOpen Access
Reflection of neuroblastoma intratumor heterogeneity in the new OHC‐NB1 disease model
International Journal of Cancer·2019· 11 citedOpen Access
The <i>FRA14B</i> common fragile site maps to a region prone to somatic and germline rearrangements within the large <i>GPHN</i> gene
Genes Chromosomes and Cancer·2018· 6 cited
Establishment of an Immortalized Skin Keratinocyte Cell Line Derived from the Animal Model Mastomys coucha
PLoS ONE·2016· 8 citedOpen Access
Telomerase activation by genomic rearrangements in high-risk neuroblastoma
Nature·2015· 577 citedOpen Access
Molecular characterization of common fragile sites as a strategy to discover cancer susceptibility genes
Cellular and Molecular Life Sciences·2014· 19 citedOpen Access
Instability at the FRA8I common fragile site disrupts the genomic integrity of the KIAA0146, CEBPD and PRKDC genes in colorectal cancer
Cancer Letters·2013· 11 cited
CDK4 inhibition restores G₁-S arrest in<i><i>MYCN</i>-</i>amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage
Cell Cycle·2013· 63 citedOpen Access
Low p14ARF expression in neuroblastoma cells is associated with repressed histone mark status, and enforced expression induces growth arrest and apoptosis
Human Molecular Genetics·2013· 13 cited
HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment
Journal of Neuro-Oncology·2012· 129 cited
Genomic rearrangements at the FRA2H common fragile site frequently involve non-homologous recombination events across LTR and L1(LINE) repeats
Human Genetics·2012· 15 cited
The FRA2C common fragile site maps to the borders of MYCN amplicons in neuroblastoma and is associated with gross chromosomal rearrangements in different cancers
Human Molecular Genetics·2011· 44 citedOpen Access
MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival
Cell Death and Differentiation·2011· 153 citedOpen Access
Neuroblastoma susceptibility genes in human FRAGILOME sequences
Cancer Genetics and Cytogenetics·2010
Gephyrin and neurexin 3 are new large common fragile site (cFS) genes frequently rearranged in different human cancers
Cancer Genetics and Cytogenetics·2010
Genomic instability within the short arm of chromosome 1 in colorectal cancer
Cancer Genetics and Cytogenetics·2010
Activation of common fragile sites as a possible cause of chromosome 8 instability in colorectal cancer
Cancer Genetics and Cytogenetics·2010
The cancer FRAGILOME: a strategy for the discovery of new biomarkers
Cancer Genetics and Cytogenetics·2010
Generation and Characterization of Novel Local and Metastatic Human Neuroblastoma Variants
Neoplasia·2008· 23 citedOpen Access
Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro
Cancer Letters·2008· 30 cited
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Frequent Co-authors

Manfred Schwab(29), Frank Westermann(10), Andreas Claas(9), Lena M. Brueckner(8), Raffaella Corvi(6), Christian Praml(6), Evgeny Sagulenko(6), Volker Ehemann(5), M. Schwab(5), Lukas C. Amler(5), Matthias Fischer(4), Jens Guido Schmitt(4), Daniel Dreidax(3), Jessica Theißen(3), Marc Zapatka(3), Olaf Witt(3), Hedwig E. Deubzer(3), Diana Zheglo(3), P. Schlag(3), Siegfried Scherneck(3)