R. Claudio Aguilar

Purdue University West Lafayette — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index4.6kcitations68works0.02yr avg
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Research Topics

Cellular transport and secretion(37), Glycosylation and Glycoproteins Research(13), Fungal and yeast genetics research(8), Endoplasmic Reticulum Stress and Disease(8), Genetic and Kidney Cyst Diseases(8)

Publications68 total

Heterogeneity in Lowe Syndrome: Mutations Affecting the Phosphatase Domain of OCRL1 Differ in Impact on Enzymatic Activity and Severity of Cellular Phenotypes
Biomolecules·2023· 6 citedOpen Access
Yeast and Mammalian Epsins Use Different Determinants for Localization and Function: Role of Clathrin/AP2/Ubiquitin Binding Motifs and Poly-Glutamine Stretches
2022Open Access
The Future of Genetic Disease Studies: Assembling an Updated Multidisciplinary Toolbox
Frontiers in Cell and Developmental Biology·2022· 1 citedOpen Access
Adaptor Proteins: Inter-Organelle Traffic Controllers
Elsevier eBooks·2022
Genotype &amp; phenotype in Lowe Syndrome: specific <i>OCRL1</i> patient mutations differentially impact cellular phenotypes
Human Molecular Genetics·2021· 18 citedOpen Access
MOLECULAR DETERMINANTS OF THE ENDOCYTIC PROTEIN EPSIN CONTROLLING ITS LOCALIZATION AND FUNCTION IN CANCER CELL MIGRATION AND INVASION
2020· 2 citedOpen Access
The Na+ pump Ena1 is a yeast epsin-specific cargo requiring its ubiquitylation and phosphorylation sites for internalization
Journal of Cell Science·2020· 12 citedOpen Access
Lowe syndrome patient cells display mTOR- and RhoGTPase-dependent phenotypes alleviated by rapamycin and statins
Human Molecular Genetics·2020· 13 citedOpen Access
Allosteric activators of Ocrl1: a novel therapeutic strategy against Lowe syndrome
The FASEB Journal·2020
Ubiquitination and Phosphorylation are Independently Required for Epsin-Mediated Internalization of Cargo in <i>S. cerevisiae</i>
2020Open Access
A novel, safe, fast and efficient treatment for Her2‐positive and negative bladder cancer utilizing an EGF‐anthrax toxin chimera
International Journal of Cancer·2019· 29 citedOpen Access
Differential effect of <i>OCRL1</i> patient mutations on protein localization, and sensitivity to FDA‐approved drug suppression of cellular phenotypes associated with Lowe syndrome
The FASEB Journal·2018
Kidney-differentiated cells derived from Lowe Syndrome patient’s iPSCs show ciliogenesis defects and Six2 retention at the Golgi complex
PLoS ONE·2018· 15 citedOpen Access
Epsin
2017
The Information Content of Glutamine-Rich Sequences Define Protein Functional Characteristics
Proceedings of the IEEE·2016· 6 citedOpen Access
Granulocyte colony-stimulating factor (G-CSF) upregulates β1 integrin and increases migration of human trophoblast Swan 71 cells via PI3K and MAPK activation
Experimental Cell Research·2016· 27 citedOpen Access
Role of Ocrl1 and Inpp5E in primary cilia assembly and maintenance: a phosphatidylinositol phosphatase relay system?
Research and Reports in Biology·2016· 3 citedOpen Access
Epsin
2016
Adaptor Proteins: Inter-Organelle Traffic Controllers
Elsevier eBooks·2015
MAPKs and PI3K/Akt pathways are involved in G-CSF-induced migration in a human trophoblast cell line
Placenta·2015· 3 cited
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Frequent Co-authors

Juan S. Bonifacino(13), Kayalvizhi Madhivanan(11), Debarati Mukherjee(9), Claudia B. Hanna(8), Brian G. Coon(7), Arpita Sen(7), Swetha Ramadesikan(6), Hiroshi Ohno(5), Beverly Wendland(5), Leonor P. Roguin(5), Viviana C. Blank(4), Esteban C. Dell’Angelica(3), Lisa M. Hartnell(3), Takashi Saito(3), Wen-Chieh Hsieh(3), William A. Gahl(2), Rosa Puertollano(2), Inna Gorshkova(2), Robert J. Crouch(2), Hadiya A. Watson(2)