Stewart O. Sage

University of Cambridge — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

56h-index7.9kcitations148works0.02yr avg
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Research Topics

Ion channel regulation and function(46), Ion Channels and Receptors(44), Protein Kinase Regulation and GTPase Signaling(25), Platelet Disorders and Treatments(25), Receptor Mechanisms and Signaling(23)

Publications146 total

Platelet Signal Transduction: Calcium
2025
Calcium sequestration by human platelet acidic organelles is regulated by the actin cytoskeleton and autocrine 5-hydroxytryptamine
Cell Calcium·2021· 3 citedOpen Access
Two novel, putative mechanisms of action for citalopram-induced platelet inhibition
Scientific Reports·2018· 19 citedOpen Access
Citalopram inhibits platelet function independently of SERT-mediated 5-HT transport
Scientific Reports·2018· 23 citedOpen Access
Fine-tuning of store-operated calcium entry by fast and slow Ca2+-dependent inactivation: Involvement of SARAF
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2017· 26 cited
Platelet Signalling: Calcium
2017· 18 cited
TRP-Na+/Ca2+ Exchanger Coupling
Advances in experimental medicine and biology·2016· 21 cited
Conventional protein kinase C isoforms differentially regulate ADP- and thrombin-evoked Ca2+ signalling in human platelets
Cell Calcium·2015· 11 citedOpen Access
Zinc is a transmembrane agonist that induces platelet activation in a tyrosine phosphorylation-dependent manner
Metallomics·2015· 50 citedOpen Access
Pericellular Ca<sup>2+</sup>recycling potentiates thrombin-evoked Ca<sup>2+</sup>signals in human platelets
Physiological Reports·2013· 19 citedOpen Access
The TRPV1 ion channel is expressed in human but not mouse platelets
Platelets·2013· 8 citedOpen Access
STIM1 tyrosine-phosphorylation is required for STIM1-Orai1 association in human platelets
Cellular Signalling·2012· 38 cited
Monitoring the intracellular store Ca2+ concentration in agonist‐stimulated, intact human platelets by using Fluo‐5N
Journal of Thrombosis and Haemostasis·2010· 28 cited
Src family tyrosine kinases activate thrombin-induced non-capacitative cation entry in human platelets
Platelets·2010· 13 cited
Phorbol ester‐evoked Ca2+signaling in human platelets is via autocrine activation of P2X1 receptors, not a novel non‐capacitative Ca2+entry
Journal of Thrombosis and Haemostasis·2010· 19 cited
Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation
Journal of Biological Chemistry·2009· 129 citedOpen Access
A key role for dense granule secretion in potentiation of the Ca2+ signal arising from store-operated calcium entry in human platelets
Cell Calcium·2009· 35 cited
A role for TRPV1 in agonist‐evoked activation of human platelets
Journal of Thrombosis and Haemostasis·2008· 60 cited
Biochemical and functional properties of the store-operated Ca2+ channels
Cellular Signalling·2008· 68 cited
TRPC channels and store-operated Ca2+ entry
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2008· 136 cited
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Frequent Co-authors

Juan A. Rosado(19), Johan W. M. Heemskerk(9), T J Rink(8), Alan G.S. Harper(4), Sharon Brownlow(4), Ginés M. Salido(4), Martyn P. Mahaut‐Smith(3), Paul Sargeant(3), Pedro C. Redondo(3), Matthew T. Harper(3), Marion A.H. Feijge(2), С. М. Марченко(2), José A. Pariente(2), John S. Hoyland(2), William T. Mason(2), J E Merritt(1), Trevor J. Hallam(1), TJ Rink(1), Amanda B. Mackenzie(1), Richard W. Farndale(1)