Aaron Schain

Beth Israel Deaconess Medical Center — United States

Medicine · Health Sciences

16h-index2.6kcitations29works1.02yr avg
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Research Topics

Migraine and Headache Studies(17), Trigeminal Neuralgia and Treatments(9), Neuroinflammation and Neurodegeneration Mechanisms(5), Botulinum Toxin and Related Neurological Disorders(4), Neuroscience of respiration and sleep(4)

Publications29 total

OnabotulinumtoxinA Alters Pro- and Anti-Inflammatory Dural Macrophage Response to CSD in Female Mice
Toxicon·2026
OnabotulinumtoxinA alters pro- and anti-inflammatory dural macrophage response to CSD in female mice
Cephalalgia·2025· 3 citedOpen Access
Label-free and fluorescence imaging of oligodendrocytes and myelin
npj Imaging·2025Open Access
OnabotulinumtoxinA affects cortical recovery period but not occurrence or propagation of cortical spreading depression in rats with compromised blood–brain barrier
Pain·2021· 5 citedOpen Access
Combined onabotulinumtoxinA/atogepant treatment blocks activation/sensitization of high-threshold and wide-dynamic range neurons
Cephalalgia·2020· 43 citedOpen Access
Activation of Peripheral and Central Trigeminovascular Neurons by Seizure: Implications for Ictal and Postictal Headache
Journal of Neuroscience·2020· 9 citedOpen Access
Extracranial Injections of OnabotulinumtoxinA in Combination with Intravenous Injection of Atogepant Attenuates Activation and Sensitization of HT and WDR Neurons by CSD (4287)
Neurology·2020· 1 cited
Celecoxib reduces cortical spreading depression–induced macrophage activation and dilatation of dural but not pial arteries in rodents: implications for mechanism of action in terminating migraine attacks
Pain·2019· 16 citedOpen Access
Fremanezumab and its isotype slow propagation rate and shorten cortical recovery period but do not prevent occurrence of cortical spreading depression in rats with compromised blood–brain barrier
Pain·2019· 39 citedOpen Access
Fluorescently-labeled fremanezumab is distributed to sensory and autonomic ganglia and the dura but not to the brain of rats with uncompromised blood brain barrier
Cephalalgia·2019· 92 citedOpen Access
Exploring the effects of extracranial injections of botulinum toxin type A on prolonged intracranial meningeal nociceptors responses to cortical spreading depression in female rats
Cephalalgia·2019· 43 citedOpen Access
CSD-Induced Arterial Dilatation and Plasma Protein Extravasation Are Unaffected by Fremanezumab: Implications for CGRP's Role in Migraine with Aura
Journal of Neuroscience·2019· 74 citedOpen Access
Activation of pial and dural macrophages and dendritic cells by cortical spreading depression
Annals of Neurology·2018· 103 citedOpen Access
Fremanezumab—A Humanized Monoclonal Anti-CGRP Antibody—Inhibits Thinly Myelinated (Aδ) But Not Unmyelinated (C) Meningeal Nociceptors
Journal of Neuroscience·2017· 186 citedOpen Access
Selective Inhibition of Trigeminovascular Neurons by Fremanezumab: A Humanized Monoclonal Anti-CGRP Antibody
Journal of Neuroscience·2017· 156 citedOpen Access
Sensitization and Photophobia in Migraine
2017· 1 cited
In vivo imaging of CSD-induced activation of resident meningeal immune cells: implications for activation of meningeal nociceptors (S47.003)
Neurology·2017
Prolonged activation and sensitization of central trigeminovascular neurons by a single wave of CSD in male and female rats (P2.145)
Neurology·2017
Cortical spreading depression closes the paravascular space and impairs glymphatic flow: Implications for migraine headache. (S47.001)
Neurology·2017
What does the humanized monoclonal anti-CGRP antibody (TEV-48125) teach us about the perception of migraine headache? (P2.159)
Neurology·2017
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Frequent Co-authors

Rami Burstein(22), Andrew M. Strassman(19), Agustin Melo‐Carrillo(17), Jaime Grutzendler(7), Mitchell F. Brin(6), Jennifer Stratton(5), Aubrey Manack Adams(5), Carlo Condello(4), Rodrigo Noseda(4), Rony‐Reuven Nir(3), Sait Ashina(3), Ron S. Broide(3), Peng Yuan(2), Robert Hill(2), Catherine Buettner(2), Carlton Perry(2), Pamela G. Blake(2), Amy Brideau-Andersen(2), Subhash Kulkarni(2), Rony Reuven-Nir(2)