David Chuang

The University of Texas Southwestern Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

47h-index7.3kcitations201works20.72yr avg
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Research Topics

Metabolism and Genetic Disorders(101), Biochemical Acid Research Studies(100), Enzyme Structure and Function(33), Biochemical and Molecular Research(29), Diet and metabolism studies(27)

Publications201 total

Biosynthesis of minimal C-phycocyanin chromophore assemblies in <i>E. coli</i> provides a platform to dissect protein-mediated tuning of exciton transfer
2025Open Access
<i>BCKDHA-BCKDHB</i> digenic gene therapy restores metabolic homeostasis in two mouse models and a calf with classic maple syrup urine disease
Science Translational Medicine·2025· 5 cited
Bicyclic Inhibitors of Branched-Chain α-Keto Acid Dehydrogenase Kinase (BDK) with In Vivo Activity
ACS Medicinal Chemistry Letters·2024· 1 citedOpen Access
Maple syrup urine disease: biochemical, clinical, and therapeutic considerations
Elsevier eBooks·2024
List of Contributors
Elsevier eBooks·2024Open Access
The intrinsic substrate specificity of the human tyrosine kinome
Nature·2024· 118 citedOpen Access
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis
Nature Metabolism·2022· 43 citedOpen Access
List of contributors
Elsevier eBooks·2020
Maple syrup urine disease: biochemical, clinical and therapeutic considerations
Elsevier eBooks·2020· 2 cited
Real-time hyperpolarized 13C magnetic resonance detects increased pyruvate oxidation in pyruvate dehydrogenase kinase 2/4–double knockout mouse livers
Scientific Reports·2019· 21 citedOpen Access
Targeting BCAA Catabolism to Treat Obesity-Associated Insulin Resistance
Diabetes·2019· 296 citedOpen Access
Therapeutic Effect of Targeting Branched‐Chain Amino Acid Catabolic Flux in Pressure‐Overload Induced Heart Failure
Journal of the American Heart Association·2019· 77 citedOpen Access
Comparison of Maximal Forces Produced During Different Chokehold Techniques
Medicine & Science in Sports & Exercise·2019
In vivo assessment of increased oxidation of branched-chain amino acids in glioblastoma
Scientific Reports·2019· 37 citedOpen Access
Integration of BCAA and Lipid Metabolism by the BCKDH Kinase and Phosphatase
Diabetes·2018
The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase
Cell Metabolism·2018· 339 citedOpen Access
A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity
Journal of Biological Chemistry·2018· 33 citedOpen Access
Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice
Molecular Metabolism·2018· 44 citedOpen Access
Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors
Journal of Medicinal Chemistry·2017· 37 citedOpen Access
Track-Based Aerodynamic Testing of a Heavy-Duty Vehicle: Coast-Down Measurements
SAE International journal of commercial vehicles·2016· 11 cited
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Frequent Co-authors

Richard Wynn(29), Jacinta L. Chuang(20), Shih-Chia Tso(9), Masato Kato(6), Mischa Machius(6), Kim S. Lau(6), W.J. Gui(5), Xiangbing Qi(5), Jun Li(5), Jiu-Li Song(5), Chad A. Brautigam(5), Diana R. Tomchick(5), Susan M. Hutson(5), Cheng‐Yang Wu(4), Steven J. Ludtke(4), Wah Chiu(4), James Davie(4), C. Fisher(4), Haipeng Sun(3), Yibin Wang(3)