Paula M. van Heijningen

Erasmus MC — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

9h-index321citations16works4.52yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Connective tissue disorders research(12), Aortic aneurysm repair treatments(11), Aortic Disease and Treatment Approaches(9), DNA Repair Mechanisms(1), Mitochondrial Function and Pathology(1)

Publications16 total

Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice
npj Aging·2024· 7 citedOpen Access
Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice
Molecular Imaging and Biology·2024· 2 citedOpen Access
Pre-Operative Fasting Provides Long Term Protection Against Chronic Renal Damage Induced by Ischaemia Reperfusion Injury in Wild Type and Aneurysm Prone Fibulin-4 Mice
European Journal of Vascular and Endovascular Surgery·2020· 7 citedOpen Access
Abstract 15335: Hybrid Optical and CT Imaging Reveals Increased Matrix Metalloprotease Activity and Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice
Circulation·2019
Inflammation and TGF-β Signaling Differ between Abdominal Aneurysms and Occlusive Disease
Journal of Cardiovascular Development and Disease·2019· 11 citedOpen Access
Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation
Cardiovascular Research·2018· 78 citedOpen Access
Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling
EBioMedicine·2016· 39 citedOpen Access
AT1-receptor blockade, but not renin inhibition, reduces aneurysm growth and cardiac failure in fibulin-4 mice
Journal of Hypertension·2016· 18 citedOpen Access
Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels
Scientific Reports·2015· 29 citedOpen Access
Abstract 382: Reduced Mitochondrial Function and Metabolic Dysregulation in Aneurysmal Fibulin-4 Mice.
Circulation Research·2015
Reduced Mitochondrial Function and Metabolic Dysregulation in Aneurysmal Fibulin-4 Mice.
Circulation Research·2015
Extracellular Matrix Defects in Aneurysmal Fibulin-4 Mice Predispose to Lung Emphysema
PLoS ONE·2014· 19 citedOpen Access
Absence of Cardiovascular Manifestations in a Haploinsufficient Tgfbr1 Mouse Model
PLoS ONE·2014· 10 citedOpen Access
Abstract 15331: Reduced Fibulin-4 Expression Induces Cardiomyocyte Remodeling and Dilated Cardiomyopathy
Circulation·2011
Impaired Vascular Contractility and Aortic Wall Degeneration in Fibulin-4 Deficient Mice: Effect of Angiotensin II Type 1 (AT1) Receptor Blockade
PLoS ONE·2011· 43 citedOpen Access
Multimodality Imaging Reveals a Gradual Increase in Matrix Metalloproteinase Activity at Aneurysmal Lesions in Live Fibulin-4 Mice
Circulation Cardiovascular Imaging·2010· 58 citedOpen Access

Frequent Co-authors

Jeroen Essers(16), Ingrid van der Pluijm(11), Marcel Vermeij(10), Nicole van Vliet(9), Roland Kanaar(9), Luuk te Riet(7), Arne IJpma(5), Ivo Que(5), Eric L. Kaijzel(5), Yanto Ridwan(5), Bibi S. van Thiel(5), Jeroen Demmers(4), Hiromi Yanagisawa(4), Natasja W. M. Ramnath(4), A.H. Jan Danser(4), Hence J.M. Verhagen(4), Joyce Burger(3), Léa‐Jeanne Ringuette(3), Devashish Das(3), Reinier van der Linden(3)