Adam L. MacLean

QB3 — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index2.0kcitations134works1.22yr avg
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Research Topics

Single-cell and spatial transcriptomics(25), Cancer Cells and Metastasis(24), Immune cells in cancer(23), Gene Regulatory Network Analysis(19), Nanoparticle-Based Drug Delivery(13)

Publications134 total

Supplementary Figures from Myeloid-Derived Suppressor–Cell Dynamics Control Outcomes in the Metastatic Niche
2025Open Access
Supplementary Text and Tables from Myeloid-Derived Suppressor–Cell Dynamics Control Outcomes in the Metastatic Niche
2025Open Access
Gene regulatory network inference with popInfer reveals the dynamic regulation of hematopoietic stem cell quiescence
iScience·2025· 1 citedOpen Access
Chronic myeloid leukemia (CML) evolution is not encoded in single-cell microstates, but emerges from population-level macrostates
Blood·2025Open Access
735 T cell interactions and B cell activation mediate response to treatment with entinostat and checkpoint inhibitors in metastatic breast cancer
Regular and Young Investigator Award Abstracts·2025Open Access
Beyond RECIST: mathematical modeling and Bayesian inference reveal the importance of immune parameters in metastatic breast cancer
2025Open Access
Cancer systems immunology reveals myeloid—T cell interactions and B cell activation mediate response to checkpoint inhibition in metastatic breast cancer
2025Open Access
Abstract P1-04-21: Suppressing suppression: histone deacetylase inhibition primes the metastatic tumor microenvironment to respond to checkpoint inhibition by dynamic rewiring of cell interactions
Clinical Cancer Research·2025
Inference of marker genes of subtle cell state changes via iterative logistic regression
2025· 1 citedOpen Access
Transition paths across the epithelial-mesenchymal transition landscape are dictated by network logic
Development·2025· 3 citedOpen Access
Longitudinal single cell RNA-sequencing reveals evolution of micro- and macro-states in chronic myeloid leukemia
2025Open Access
Modeling the dynamics of EMT reveals genes associated with pan-cancer intermediate states and plasticity
npj Systems Biology and Applications·2025· 6 citedOpen Access
Abstract A068: HDAC1 and HDAC3 inhibition decreases myeloid derived suppressor cell function through STAT3-mediated apoptosis
Cancer Immunology Research·2025
Abstract B020: Dual checkpoint inhibition using anti-PD-1 and anti-CTLA-4 in combination with entinostat increases treatment efficacy and decreases suppressive signaling between myeloid cells and T cells in breast-to-lung metastasis
Cancer Immunology Research·2025
Data-driven model discovery and model selection for noisy biological systems
PLoS Computational Biology·2025· 4 citedOpen Access
The RNA Exosome Maintains Cellular RNA Homeostasis by Controlling Transcript Abundance in the Brain
SSRN Electronic Journal·2025Open Access
Transition paths across the EMT landscape are dictated by network logic
2024Open Access
Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life
Nature Communications·2024· 8 citedOpen Access
874 Epigenetic modulation of myeloid derived suppressor cells decreases suppressive signaling through the STAT3 pathway
Regular and Young Investigator Award Abstracts·2024Open Access
770 Entinostat attenuates myeloid cell immunosuppression and increases the efficacy of checkpoint inhibition in a HER2+ mouse model of breast-to-lung metastasis
Regular and Young Investigator Award Abstracts·2024Open Access
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Frequent Co-authors

Qing Nie(15), Michael P. H. Stumpf(10), Halie M. Rando(7), Alexandra Lee(7), Ronan Lordan(7), Elizabeth Sell(7), Nils Wellhausen(7), Anthony Gitter(7), Casey S. Greene(7), Megan K. Rommelfanger(5), Ashwin N. Skelly(5), John J. Dziak(5), Marouen Ben Guebila(5), Simina M. Boca(5), Stephen Capone(5), YoSon Park(5), Christian Brueffer(5), James Brian Byrd(5), Jeremy P. Kamil(5), Ryan Velazquez(5)