Lester M. Bornheim

Exelixis (United States) — United States

Medicine · Health Sciences

26h-index2.0kcitations40works0.02yr avg
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Research Topics

Cannabis and Cannabinoid Research(23), Pharmacogenetics and Drug Metabolism(15), Drug Transport and Resistance Mechanisms(6), Pancreatic function and diabetes(6), Diet, Metabolism, and Disease(6)

Publications40 total

Pharmacological Abrogation of S-Phase Checkpoint Enhances the Anti-Tumor Activity of Gemcitabine In Vivo
Cell Cycle·2007· 133 citedOpen Access
Cannabinoid-induced alterations in brain disposition of drugs of abuse 11Abbreviations: THC, tetrahydrocannabinol; CBD, cannabidiol; PCP, phencyclidine; MDMA, 3,4-methylenedioxyphenyl-methamphetamine HCl.
Biochemical Pharmacology·2001· 70 cited
The Effects of Phencyclidine Pretreatment on Cocaine-Mediated Hepatotoxicity in Mice
Toxicology and Applied Pharmacology·2001· 9 cited
Effects of unsaturated side-chain analogs of tetrahydrocannabinol on cytochromes P450
Biochemical Pharmacology·2000· 6 cited
The Glucocorticoid Receptor Is Essential for Induction of Cytochrome P-4502B by Steroids but Not for Drug or Steroid Induction of CYP3A or P-450 Reductase in Mouse Liver
Drug Metabolism and Disposition·2000· 103 cited
Ethynylestradiol-Mediated Induction of Hepatic CYP3A9 in Female Rats: Implication for Cyclosporine Metabolism
Drug Metabolism and Disposition·1999· 27 cited
Identification of the Heme-Modified Peptides from Cumene Hydroperoxide-Inactivated Cytochrome P450 3A4
Biochemistry·1998· 57 cited
Characterization of Cytochrome P450 3A Inactivation by Cannabidiol:  Possible Involvement of Cannabidiol-Hydroxyquinone as a P450 Inactivator
Chemical Research in Toxicology·1998· 77 cited
Oleamide Potentiates Benzodiazepine-Sensitive gamma-Aminobutyric Acid Receptor Activity but Does Not Alter Minimum Alveolar Anesthetic Concentration
Anesthesia & Analgesia·1998· 55 cited
Oleamide Potentiates Benzodiazepine-Sensitive gamma-Aminobutyric Acid Receptor Activity but Does Not Alter Minimum Alveolar Anesthetic Concentration
Anesthesia & Analgesia·1998· 42 cited
Effect of Cytochrome P450 Inducers on Cocaine-Mediated Hepatotoxicity
Toxicology and Applied Pharmacology·1998· 48 cited
Dual Effects of Anandamide on NMDA Receptor‐Mediated Responses and Neurotransmission
Journal of Neurochemistry·1998· 205 cited
Determination of Esterase-Catalyzed Cocaine Metabolite Formation by High-Performance Liquid Chromatography with Ultraviolet Detection
Journal of Chromatographic Science·1997· 6 citedOpen Access
Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes
Xenobiotica·1996· 63 cited
Anandamide hydroxylation by brain lipoxygenase:metabolite structures and potencies at the cannabinoid receptor
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism·1995· 130 cited
A Universal Approach to the Expression of Human and Rabbit Cytochrome P450s of the 2C Subfamily inEscherichia coli
Archives of Biochemistry and Biophysics·1995· 145 cited
Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain.
Drug Metabolism and Disposition·1995· 77 cited
Microsomal cytochrome P450-mediated liver and brain anandamide metabolism
Biochemical Pharmacology·1995· 68 cited
Induction and genetic regulation of mouse hepatic cytochrome P450 by cannabidiol
Biochemical Pharmacology·1994· 38 cited
The Effect of Cannabidiol on Mouse Hepatic Microsomal Cytochrome P450-Dependent Anandamide Metabolism
Biochemical and Biophysical Research Communications·1993· 63 cited
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Frequent Co-authors

Maria Almira Correia(11), Aidan J. Hampson(4), C. Spencer Yost(3), Andrew T. Gray(3), Dmitri Leonoudakis(3), Leslie Z. Benet(3), M.A.S. Correia(3), John R. Cashman(3), Leslie D. Olsen(3), Judy L. Raucy(2), K.Y. Kim(2), Michael Reid(2), E. Thomas Everhart(2), Jianmin Li(2), Patricia Caldera(2), Steven Wrighton(2), Allan E. Rettie(2), Donald D. Koblin(2), Kevin M. Smith(2), Massimo Scanziani(1)