David J. Shealy

Medicine · Health Sciences

29h-index6.4kcitations52works0.02yr avg
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Research Topics

Monoclonal and Polyclonal Antibodies Research(14), Rheumatoid Arthritis Research and Therapies(8), Immune Response and Inflammation(7), Inflammatory Bowel Disease(6), Immunotherapy and Immune Responses(6)

Publications51 total

Data from Tumor necrosis factor deficiency inhibits mammary tumorigenesis and a tumor necrosis factor neutralizing antibody decreases mammary tumor growth in neu/erbB2 transgenic mice
2023Open Access
Supplementary Data from Tumor necrosis factor deficiency inhibits mammary tumorigenesis and a tumor necrosis factor neutralizing antibody decreases mammary tumor growth in neu/erbB2 transgenic mice
2023Open Access
Data from Tumor necrosis factor deficiency inhibits mammary tumorigenesis and a tumor necrosis factor neutralizing antibody decreases mammary tumor growth in neu/erbB2 transgenic mice
2023Open Access
Supplementary Data from Tumor necrosis factor deficiency inhibits mammary tumorigenesis and a tumor necrosis factor neutralizing antibody decreases mammary tumor growth in neu/erbB2 transgenic mice
2023Open Access
PD-L1– and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease
JCI Insight·2019· 64 citedOpen Access
Epithelial TNF Receptor Signaling Promotes Mucosal Repair in Inflammatory Bowel Disease
The Journal of Immunology·2017· 134 citedOpen Access
Role of the inflammatory response in the hemorrhagic syndrome induced by the hemolymph of the caterpillar Lonomia achelous
Toxicon·2016· 3 cited
THU0042 Preclinical Characterization of Sirukumab, a Human Monoclonal Antibody that Targets Human Interleukin-6 Signaling
Annals of the Rheumatic Diseases·2015· 2 cited
FRI0069 Neutralization of IL6 by Sirukumab (SIR) Inhibits Inflammation and Cellular Stress in a Human Vascular Surrogate System of Atherosclerosis
Annals of the Rheumatic Diseases·2015· 3 cited
Divergent Gene Activation in Peripheral Blood and Tissues of Patients with Rheumatoid Arthritis, Psoriatic Arthritis and Psoriasis following Infliximab Therapy
PLoS ONE·2014· 15 citedOpen Access
Su1992 TNF Mediates β-Catenin Activation in Intestinal Stem Cells During Colitis
Gastroenterology·2014
Anti–Tumor Necrosis Factor α Prevents Bowel Fibrosis Assessed by Messenger RNA, Histology, and Magnetization Transfer MRI in Rats With Crohnʼs Disease
Inflammatory Bowel Diseases·2013· 44 citedOpen Access
Discovery and mechanism of ustekinumab
mAbs·2011· 324 citedOpen Access
Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus
The Journal of Immunology·2011· 1.2k citedOpen Access
Evaluation of an Anti-Tumor Necrosis Factor Therapeutic in a Mouse Model of Niemann-Pick C Liver Disease
PLoS ONE·2010· 18 citedOpen Access
Characterization of golimumab, a human monoclonal antibody specific for human tumor necrosis factor α
mAbs·2010· 239 citedOpen Access
TNF-α drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice
Journal of Clinical Investigation·2009· 204 citedOpen Access
Tumor necrosis factor deficiency inhibits mammary tumorigenesis and a tumor necrosis factor neutralizing antibody decreases mammary tumor growth in neu/erbB2 transgenic mice
Molecular Cancer Therapeutics·2009· 53 citedOpen Access
Evaluation of anti-IL-6 monoclonal antibody therapy using murine type II collagen-induced arthritis
Journal of Inflammation·2009· 41 citedOpen Access
Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast‐enhanced magnetic resonance imaging
Arthritis & Rheumatism·2008· 46 citedOpen Access
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Frequent Co-authors

Jeffrey A. Mattis(6), Bernard J. Scallon(4), Carrie Wagner(4), D.J. Hnatowich(4), Christopher T. Ritchlin(4), Edward M. Schwarz(4), Mary Ann Warren(4), Suzanne F. Shoemaker(4), Margot M. Ip(4), Scott A. Siegel(3), Peter E. Daddona(3), Ann Cai(3), Amy S. Rosenberg(3), Mary Ann Mascelli(3), Thomas W. Griffin(3), Mary Rusckowski(3), Steven T. Proulx(3), Edmund Kwok(3), Zhigang You(3), Christopher A. Beck(3)