Timothy Clair

Biochemistry, Genetics and Molecular Biology · Life Sciences

44h-index5.1kcitations96works0.02yr avg
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Research Topics

Adenosine and Purinergic Signaling(12), Enzyme function and inhibition(12), Sphingolipid Metabolism and Signaling(11), Chemical Synthesis and Analysis(10), Protein Kinase Regulation and GTPase Signaling(9)

Publications96 total

ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2)
Atlas of Genetics and Cytogenetics in Oncology and Haematology·2011· 1 citedOpen Access
Phospholipase Cγ Activation Drives Increased Production of Autotaxin in Endothelial Cells and Lysophosphatidic Acid-Dependent Regression
Molecular and Cellular Biology·2010· 35 citedOpen Access
For Science, No Escape from Politics
Science·2009· 1 cited
Novel point mutations attenuate autotaxin activity
Lipids in Health and Disease·2009· 7 citedOpen Access
Regulation of Lysophosphatidic Acid Receptor Expression and Function in Human Synoviocytes: Implications for Rheumatoid Arthritis?
Molecular Pharmacology·2007· 83 cited
Sphingosine-1-phosphate initiates rapid retraction of pseudopodia by localized RhoA activation
Cellular Signalling·2007· 10 citedOpen Access
Trichostatin A and 5-aza-2′-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors
Cancer Letters·2007· 11 citedOpen Access
Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression To Suppress Colon Carcinoma Cell Invasion
Molecular and Cellular Biology·2006· 203 citedOpen Access
The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: Down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin
Biochemical and Biophysical Research Communications·2005· 28 cited
Autotaxin (lysoPLD/NPP2) protects fibroblasts from apoptosis through its enzymatic product, lysophosphatidic acid, utilizing albumin-bound substrate
Biochemical and Biophysical Research Communications·2005· 30 cited
Physiological Mechanisms of Tumor-Cell Invasion and Migration
Physiology·2005· 139 cited
L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin
Lipids in Health and Disease·2005· 45 citedOpen Access
Protection against group A streptococcal infection by vaccination with self-adjuvanting lipid core M protein peptides
Vaccine·2005· 37 cited
L-histidine inhibits production of lysophosphatidic acid by the tumor-associated cytokine, autotaxin
2005
Group A streptococcal vaccine delivery by immunization with a self-adjuvanting M protein-based lipid core peptide construct.
PubMed·2004· 15 cited
Microarray analysis identifies Autotaxin, a tumour cell motility and angiogenic factor with lysophospholipase D activity, as a specific target of cell transformation by v-Jun
Oncogene·2003· 64 cited
Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate.
PubMed·2003· 222 cited
Hydrolysis of diadenosine polyphosphates by nucleotide pyrophosphatases/phosphodiesterases
European Journal of Biochemistry·2003· 89 citedOpen Access
Site-directed mutations in the tumor-associated cytokine, autotaxin, eliminate nucleotide phosphodiesterase, lysophospholipase D, and motogenic activities.
PubMed·2003· 53 cited
Potential of Lipid Core Peptide Technology as a Novel Self-Adjuvanting Vaccine Delivery System for Multiple Different Synthetic Peptide Immunogens
Infection and Immunity·2003· 67 citedOpen Access
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Frequent Co-authors

Yoon S. Cho‐Chung(22), Giampaolo Tortora(14), Lance A. Liotta(12), Mary L. Stracke(12), Shamsia Ally(8), Dionyssios Katsaros(7), Hoi Young Lee(5), Elliott Schiffmann(4), Stefano Pepe(4), Hiroshi Yokozaki(4), P Tagliaferri(4), Penny Yarwood(4), Eunjin Koh(3), Russell Bandle(3), Suk Woo Nam(3), Alfredo Budillon(3), Jeffrey S. Bodwin(3), Elisa C. Woodhouse(3), Colleen Olive(3), Anikó Horváth(3)