Samuel N. Young

Walter and Eliza Hall Institute of Medical Research — Australia

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index4.5kcitations53works4.02yr avg
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Research Topics

Cell death mechanisms and regulation(32), interferon and immune responses(14), Hippo pathway signaling and YAP/TAZ(10), CRISPR and Genetic Engineering(8), Phagocytosis and Immune Regulation(8)

Publications53 total

The kinase domain of RIPK3 tunes its scaffolding functions
Cell Death and Differentiation·2026· 1 citedOpen Access
Unconventional binding of calmodulin to CHK2 kinase inhibits catalytic activity
Biochemical Journal·2025Open Access
Impact of BECLIN1 haploinsufficiency on goblet cell function and susceptibility to colitis
2025Open Access
Sufficient levels of BECLIN1 are required for intestinal epithelial cell homeostasis and protection against unwanted intestinal inflammation
2025Open Access
The kinase domain of RIPK3 tunes its scaffolding functions
2025· 1 citedOpen Access
PSKH1 kinase activity is differentially modulated via allosteric binding of Ca <sup>2+</sup> sensor proteins
Proceedings of the National Academy of Sciences·2025· 3 citedOpen Access
DOP109 A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease
Journal of Crohn s and Colitis·2025Open Access
A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease
2024· 5 citedOpen Access
PSKH1 kinase activity is differentially modulated via allosteric binding of Ca <sup>2+</sup> sensor proteins
2024Open Access
Unconventional binding of Calmodulin to CHK2 kinase inhibits catalytic activity
2024· 3 citedOpen Access
Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation
Biochemical Journal·2024· 3 citedOpen Access
Large-scale genomic investigation of pediatric cholestasis reveals a novel hepatorenal ciliopathy caused by PSKH1 mutations
Genetics in Medicine·2024· 10 citedOpen Access
An immunohistochemical atlas of necroptotic pathway expression
EMBO Molecular Medicine·2024· 29 citedOpen Access
Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion
Communications Biology·2024· 1 citedOpen Access
An immunohistochemical atlas of necroptotic pathway expression
2023· 2 citedOpen Access
Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization
Nature Communications·2023· 33 citedOpen Access
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation
Nature Communications·2023· 12 citedOpen Access
It takes two to tango: structure of viral kinase PK-1 reveals a new mode of kinase regulation
Acta Crystallographica Section A Foundations and Advances·2023Open Access
The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase
Biochemical Journal·2023· 12 citedOpen Access
Co-clustering of EphB6 and ephrinB1 in trans suppresses cancer cell invasion
2022Open Access
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Frequent Co-authors

James M. Murphy(49), Joanne M. Hildebrand(25), Christopher R. Horne(22), John Silke(17), Isabelle S. Lucet(15), André L. Samson(15), Sarah E. Garnish(15), Peter E. Czabotar(14), Cheree Fitzgibbon(14), Annette V. Jacobsen(13), Andrew I. Webb(12), Jarrod J. Sandow(11), Maria C. Tanzer(10), Emma J. Petrie(10), Komal Patel(10), Lung‐Yu Liang(9), Cathrine Hall(9), Laura F. Dagley(9), Jeffrey J. Babon(8), Edwin D. Hawkins(8)