Richard Hajdu

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index4.1kcitations37works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Sphingolipid Metabolism and Signaling(16), Lipid Membrane Structure and Behavior(10), Antibiotics Pharmacokinetics and Efficacy(8), Carbohydrate Chemistry and Synthesis(5), Drug Transport and Resistance Mechanisms(4)

Publications37 total

Discovery of <i>N</i>-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia
Journal of Medicinal Chemistry·2016· 54 citedOpen Access
Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys
ACS Medicinal Chemistry Letters·2015· 18 citedOpen Access
Discovery of Benzimidazole CYP11B2 Inhibitors with <i>in Vivo</i> Activity in Rhesus Monkeys
ACS Medicinal Chemistry Letters·2015· 24 citedOpen Access
Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys - Supplementary Info
2015
Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain
ACS Medicinal Chemistry Letters·2014· 41 citedOpen Access
Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase
ACS Medicinal Chemistry Letters·2013· 36 citedOpen Access
1,3,8-Triazaspiro[4.5]decane-2,4-diones as Efficacious Pan-Inhibitors of Hypoxia-Inducible Factor Prolyl Hydroxylase 1–3 (HIF PHD1–3) for the Treatment of Anemia
Journal of Medicinal Chemistry·2012· 66 citedOpen Access
Discovery of MK-3168: A clinical PET tracer as a target engagement biomarker for FAAH
Abstracts of papers - American Chemical Society·2011
SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties
Bioorganic & Medicinal Chemistry Letters·2006· 21 citedOpen Access
Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes
Bioorganic & Medicinal Chemistry Letters·2006· 22 citedOpen Access
Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor
Bioorganic & Medicinal Chemistry Letters·2006· 36 citedOpen Access
2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors
Bioorganic & Medicinal Chemistry Letters·2006· 22 citedOpen Access
2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists
Bioorganic & Medicinal Chemistry Letters·2006· 27 citedOpen Access
Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P<sub>1</sub>) Receptor Agonists with Exceptional Selectivity against S1P<sub>2</sub> and S1P<sub>3</sub>
Journal of Medicinal Chemistry·2005· 99 citedOpen Access
Sphingosine 1-phosphate receptor agonist FTY720-phosphate causes marginal zone B cell displacement
Journal of Leukocyte Biology·2005· 57 cited
Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720
Journal of Biological Chemistry·2004· 443 citedOpen Access
A Rational Utilization of High-Throughput Screening Affords Selective, Orally Bioavailable 1-Benzyl-3-carboxyazetidine Sphingosine-1-phosphate-1 Receptor Agonists
Journal of Medicinal Chemistry·2004· 88 citedOpen Access
Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors
Bioorganic & Medicinal Chemistry Letters·2004· 30 citedOpen Access
Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720
Bioorganic & Medicinal Chemistry·2004· 52 cited
Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists
Bioorganic & Medicinal Chemistry Letters·2004· 46 citedOpen Access
page 1 of 2Next →

Frequent Co-authors

Mark Rosenbach(21), Suzanne Mandala(18), James A. Milligan(16), Jeffrey J. Hale(16), Carol Keohane(14), James D. Bergstrom(13), Deborah Card(13), Gan-Ju Shei(12), Sander G. Mills(12), Hugh Rosen(11), Gary Chrebet(11), H Kropp(7), Jon G. Sundelof(7), Lin Yan(7), Gino Salituro(6), Christopher L. Lynch(5), William Neway(4), Pei Huo(4), Elizabeth J. Quackenbush(3), R Thompson(3)