Marie‐Claire Méchin

Centre National de la Recherche Scientifique — France

Medicine · Health Sciences

26h-index2.6kcitations58works0.02yr avg
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Research Topics

Dermatology and Skin Diseases(11), Skin and Cellular Biology Research(9), Toxin Mechanisms and Immunotoxins(8), Food Allergy and Anaphylaxis Research(7), NF-κB Signaling Pathways(7)

Publications58 total

Prolyl Endopeptidase Is Involved in Filaggrinolysis and Cornification
Journal of Investigative Dermatology·2024
Deimination in epidermal barrier and hair formation
Philosophical Transactions of the Royal Society B Biological Sciences·2023· 11 citedOpen Access
Down-regulation of peptidylarginine deiminase type 1 in reconstructed human epidermis disturbs nucleophagy in the granular layer and affects barrier function
Cell Death Discovery·2023· 7 citedOpen Access
Human filaggrin monomer does not seem to be a proteasome target
Experimental Dermatology·2023· 4 citedOpen Access
ESDR204 - Is the proteasome activity involved in filaggrin breakdown?
2022
Revisiting the Roles of Filaggrin in Atopic Dermatitis
International Journal of Molecular Sciences·2022· 142 citedOpen Access
Deimination, Intermediate Filaments and Associated Proteins
International Journal of Molecular Sciences·2020· 26 citedOpen Access
L’extinction de PAD1 altère la barrière épidermique et perturbe la nucléophagie kératinocytaire
Annales de Dermatologie et de Vénéréologie·2020
Deimination and Peptidylarginine Deiminases in Skin Physiology and Diseases
International Journal of Molecular Sciences·2020· 59 citedOpen Access
284 Deciphering the pathogenesis of central centrifugal cicatricial alopecia
Journal of Investigative Dermatology·2019Open Access
Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in Reconstructed Human Epidermis
Journal of Investigative Dermatology·2019· 19 citedOpen Access
Variant <i>PADI3</i> in Central Centrifugal Cicatricial Alopecia
New England Journal of Medicine·2019· 148 citedOpen Access
Peptidylarginine deiminases and deiminated proteins at the epidermal barrier
Experimental Dermatology·2018· 21 citedOpen Access
104 In reconstructed human epidermis, peptidylarginine deiminase inhibitor Cl-amidine modulates cornification and keratinocyte autophagic flux
Journal of Investigative Dermatology·2017Open Access
Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown
Journal of Dermatological Science·2017· 67 citedOpen Access
Dans un modèle d’épiderme humain reconstruit, la protéolyse de la filaggrine est controlée, via sa désimination, par le taux d’humidité ambiant
Annales de Dermatologie et de Vénéréologie·2016
Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome
The American Journal of Human Genetics·2016· 144 citedOpen Access
Deimination of Human Hornerin Enhances its Processing by Calpain-1 and its Cross-Linking by Transglutaminases
Journal of Investigative Dermatology·2016· 19 cited
085 Through deimination, low environmental humidity drives human filaggrin breakdown
Journal of Investigative Dermatology·2016
Corrigendum to: Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis
Biological Chemistry·2016Open Access
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Frequent Co-authors

Michel Simon(36), Guy Serre(27), Hidenari Takahara(18), Rachida Nachat(10), Stéphane Chavanas(10), Laura Cau(9), Véronique Adoue(9), Fanny Coudane(6), Sijun Dong(6), Anne-Marie Schmitt(5), Akira Kawada(5), Marie Charvéron(5), Maurice Der Vartanian(5), J P Girardeau(5), Mireille Sebbag(4), Marina Guerrin(4), Julie Henry(4), Chiung‐Yueh Hsu(4), Anne‐Aurélie Raymond(4), Shibo Ying(4)