Pierre Vanderhaeghen

VIB-KU Leuven Center for Microbiology — Belgium

Neuroscience · Life Sciences

55h-index11.1kcitations157works17.62yr avg
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Research Topics

Neurogenesis and neuroplasticity mechanisms(40), Axon Guidance and Neuronal Signaling(31), Pluripotent Stem Cells Research(25), Neuroscience and Neuropharmacology Research(21), Genetics and Neurodevelopmental Disorders(19)

Publications154 total

Species-specific Rates of Fatty Acid Metabolism Set the Scale of Temporal Patterning of Corticogenesis through Protein Acetylation Dynamics
2025· 1 citedOpen Access
In vivo veritas: Xenotransplantation can help us study the development and function of human neurons in a living brain
The Transmitter·2025
A framework for neural organoids, assembloids and transplantation studies
Nature·2024· 66 citedOpen Access
Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition
Neuron·2024· 15 citedOpen Access
If you please, draw me a neuron — linking evolutionary tinkering with human neuron evolution
Current Opinion in Genetics & Development·2024· 5 citedOpen Access
CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny
Cell Reports·2024· 19 citedOpen Access
Protocol to process fresh human cerebral cortex biopsies for patch-clamp recording and immunostaining
STAR Protocols·2024· 4 citedOpen Access
SYNGAP1 deficiency disrupts synaptic neoteny in xenotransplanted human cortical neurons in vivo
Neuron·2024· 20 citedOpen Access
Metabolic mechanisms of species-specific developmental tempo
Developmental Cell·2024· 25 citedOpen Access
Linking mitochondria metabolism, developmental timing, and human brain evolution
Current Opinion in Genetics & Development·2024· 21 citedOpen Access
Repetitive CREB-DNA interactions at gene loci predetermined by CBP induce activity-dependent gene expression in human cortical neurons
Cell Reports·2023· 8 citedOpen Access
LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons
Cell·2023· 42 citedOpen Access
The microcephaly gene <i>ASPM</i> is required for the timely generation of human outer-radial glia progenitors by controlling mitotic spindle orientation
2023· 2 citedOpen Access
Human synaptic neoteny requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition
2023· 13 citedOpen Access
Subcellular mRNA localization and local translation of Arhgap11a in radial glial progenitors regulates cortical development
Neuron·2023· 30 citedOpen Access
Developmental mechanisms underlying the evolution of human cortical circuits
Nature reviews. Neuroscience·2023· 156 citedOpen Access
Mitochondria metabolism sets the species-specific tempo of neuronal development
Science·2023· 254 citedOpen Access
SYNGAP1 deficiency disrupts neoteny in human cortical neurons in vivo
2023· 4 citedOpen Access
The Microcephaly Gene &lt;i&gt;ASPM&lt;/i&gt; Is Required for the Timely Generation of Human Outer-Radial Glia Progenitors by Controlling Mitotic Spindle Orientation
SSRN Electronic Journal·2023Open Access
LRRC37B is a species-specific regulator of voltage-gated channels and excitability in human cortical neurons
2022· 4 citedOpen Access
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Frequent Co-authors

Ira Espuny-Camacho(8), Angéline Bilheu(8), John G. Flanagan(7), Nelle Lambert(7), Jelle van den Ameele(7), Adèle Herpoel(7), Franck Polleux(6), Nicolas Gaspard(5), Lara Passante(5), Luca Tiberi(5), Marie-Alexandra Lambot(4), Jordane Dimidschstein(4), Afsaneh Gaillard(4), Jérôme Bonnefont(4), Ikuo Suzuki(4), Audrey Dufour(4), Jonas Frisén(4), Ryohei Iwata(4), Tristan Bouschet(3), Kimmo A. Michelsen(3)