Nikolai Kley

Medicine · Health Sciences

35h-index5.2kcitations69works0.02yr avg
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Research Topics

Cancer-related Molecular Pathways(14), Neurofibromatosis and Schwannoma Cases(10), Receptor Mechanisms and Signaling(10), Neuropeptides and Animal Physiology(9), Cancer, Hypoxia, and Metabolism(8)

Publications69 total

Abstract 629: Delivering type I interferon to dendritic cells empowers tumor eradication and immune combination treatments
Cancer Research·2018
Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors
Bioorganic & Medicinal Chemistry Letters·2013· 16 citedOpen Access
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)
Bioorganic & Medicinal Chemistry Letters·2013· 41 citedOpen Access
Structure-Based Discovery of Novel Amide-Containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
Journal of Medicinal Chemistry·2013· 80 citedOpen Access
Structure-Based Identification of Ureas as Novel Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
Journal of Medicinal Chemistry·2013· 68 citedOpen Access
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties
Bioorganic & Medicinal Chemistry Letters·2013· 41 citedOpen Access
Abstract #3265: RGB-286638, a multi-targeted protein kinase inhibitor, induces apoptosis involving the inhibition of RNA polymerase II carboxyl-terminal domain phosphorylation and the loss of the anti-apoptotic BCL2 family member Mcl-1.
Cancer Research·2009
Scanning the Proteome for Targets of Organic Small Molecules Using Bifunctional Receptor Ligands
Chemical biology·2007
MASPIT: Three-Hybrid Trap for Quantitative Proteome Fingerprinting of Small Molecule-Protein Interactions in Mammalian Cells
Chemistry & Biology·2006· 77 citedOpen Access
A whole genome approach to identifying small molecule - protein interactions
Cancer Research·2006
Chemical proteomics and characterization of [1,3,6]-trisubstituted-pyrazolo[3,4-d]-pyrimidin-4-ones: A novel class of selective CDK/CRK inhibitors
Cancer Research·2006
Investigating the Molecular Basis of Drug Action and Response: Chemocentric Genomics and Proteomics
Current Drug Targets·2006· 5 cited
A Proteome-Wide CDK/CRK-Specific Kinase Inhibitor Promotes Tumor Cell Death in the Absence of Cell Cycle Progression
Chemistry & Biology·2005· 44 citedOpen Access
Scanning the proteome for targets of kinase inhibitors using bi-functional receptor ligands
Cellular & Molecular Biology Letters·2005
Genomics and Proteomics tools for Compound Mode-Of-Action Studies in Drug Discovery
Pharmacogenomics·2004· 13 cited
Chemical Dimerizers and Three-Hybrid Systems
Chemistry & Biology·2004· 49 cited
A Three-Hybrid Approach to Scanning the Proteome for Targets of Small Molecule Kinase Inhibitors
Chemistry & Biology·2004· 136 citedOpen Access
Functional Genomics and Proteomics: Basics, Opportunities and Challenges
2003· 1 cited
A novel p53‐inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis‐inducing factor (AIF)
FEBS Letters·2002· 116 citedOpen Access
Anti-inflammatory effect of low-dose X-irradiation and the involvement of a TGF-β 1 -induced down-regulation of leukocyte/endothelial cell adhesion
International Journal of Radiation Biology·2002· 113 cited
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Frequent Co-authors

Bernd R. Seizinger(12), Jean‐Philippe Loeffler(11), C.W. Pittius(9), V. Höllt(9), Maureen Caligiuri(7), Chase C. Smith(6), Leonard Buckbinder(5), Jean M. Whaley(5), Xiaozhang Zheng(5), Timm Baumeister(5), Alexandre J. Buckmelter(5), Karl H. Clodfelter(5), Bingsong Han(5), Yen‐Ching Ho(5), Jian Lin(5), Dominic J. Reynolds(5), Geeta Sharma(5), Zhongguo Wang(5), Peter S. Dragovich(5), Angela Oh(5)