Roger D. Zühlke

Swissmedic — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

10h-index1.9kcitations13works0.02yr avg
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Research Topics

Ion channel regulation and function(10), Cardiac electrophysiology and arrhythmias(7), Neuroscience and Neuropharmacology Research(5), Neuroscience and Neural Engineering(2), Lipid Membrane Structure and Behavior(1)

Publications13 total

Good Laboratory Practice (GLP)– guidelines for the validation of computerised systems
The Quality Assurance Journal·2007· 3 cited
Molecular basis of calmodulin tethering and Ca2+-dependent inactivation of L-type Ca2+ channels.
Journal of Biological Chemistry·2001· 13 citedOpen Access
Molecular Basis of Calmodulin Tethering and Ca2+-dependent Inactivation of L-type Ca2+ Channels
Journal of Biological Chemistry·2001· 293 citedOpen Access
Ca2+-sensitive Inactivation and Facilitation of L-type Ca2+ Channels Both Depend on Specific Amino Acid Residues in a Consensus Calmodulin-binding Motif in theα1C subunit
Journal of Biological Chemistry·2000· 189 citedOpen Access
Calmodulin supports both inactivation and facilitation of L-type calcium channels
Nature·1999· 882 cited
Ca<sup>2+</sup> channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human α<sub>1C</sub> subunit gene
FEBS Letters·1998· 76 cited
Ca <sup>2+</sup> -sensitive inactivation of L-type Ca <sup>2+</sup> channels depends on multiple cytoplasmic amino acid sequences of the α <sub>1C</sub> subunit
Proceedings of the National Academy of Sciences·1998· 189 cited
Molecular Structures Involved in L-type Calcium Channel Inactivation
Journal of Biological Chemistry·1997· 143 citedOpen Access
Oxidation of an engineered pore cysteine locks a voltage-gated K+ channel in a nonconducting state
Biophysical Journal·1996· 12 citedOpen Access
Side-chain accessibilities in the pore of a K+ channel probed by sulfhydryl-specific reagents after cysteine-scanning mutagenesis
Biophysical Journal·1995· 101 citedOpen Access
[4] Xenopus oocytes: A system for expression cloning and structure-function studies of ion channels and receptors
Methods in neurosciences·1995· 10 cited
Role of an invariant cysteine in gating and ion permeation of the voltage-sensitive K+ channel Kv2.1.
PubMed·1994· 18 cited
Ceil cultures as a test system to study lysosomotropic drug effects
European Journal of Pharmacology·1990

Frequent Co-authors

H. Réuter(7), Geoffrey S. Pitt(4), Richard W. Tsien(4), Rolf H. Joho(4), Andy Hudmon(2), Howard Schulman(2), Nikolai M. Soldatov(2), Alexandre Bouron(2), H J Zhang(2), Karl Deisseroth(1), Leonie Kurz(1), H.J. Zhang(1), Y. Liu(1), Huijuan Zhang(1), Peter M. Esch(1), Gérard Donzé(1), Bruno Eschbach(1), Stephan Hassler(1), Leo Hutter(1), Hans Peter Saxer(1)