Brian Champion

OBS Medical (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

30h-index3.4kcitations233works0.02yr avg
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Research Topics

Virus-based gene therapy research(48), CAR-T cell therapy research(34), Cancer Research and Treatments(28), Monoclonal and Polyclonal Antibodies Research(25), Viral Infectious Diseases and Gene Expression in Insects(21)

Publications232 total

1003 Tumor-specific replication and immunoactivity of aCD40-producing T-SIGn vectors
Regular and Young Investigator Award Abstracts·2024Open Access
Phase 1 clinical trial results for NG-350A, a novel transgene-armed and tumor-selective vector: Differential effects of intravenous (IV) versus intratumoral (IT) dosing on immune pharmacodynamics (PD).
Journal of Clinical Oncology·2023· 4 cited
Abstract 5746: Flexible tumor-specific cytokine and antigen delivery through the T-SIGn vector platform enables effective CAR-T cell therapy against solid tumors
Cancer Research·2023
Abstract 2740: Safe and effective delivery of antibody fragments to the solid tumor microenvironment
Cancer Research·2023· 1 cited
Supplementary Figures S1-5, Tables S1-3, Captions for Movies S1-3 from An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
2023Open Access
Data from An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
2023Open Access
Data from An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
2023Open Access
Movie S3 from An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
2023Open Access
Movie S3 from An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
2023Open Access
Movie S1 from An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
2023Open Access
Movie S2 from An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
2023Open Access
Movie S1 from An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
2023Open Access
Supplementary Figures S1-5, Tables S1-3, Captions for Movies S1-3 from An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
2023Open Access
Movie S2 from An Oncolytic Virus Expressing a T-cell Engager Simultaneously Targets Cancer and Immunosuppressive Stromal Cells
2023Open Access
1223 NG-796A: A T-SIGn vector designed to reprogram the tumor microenvironment and drive anti-tumor immunity
Regular and Young Investigator Award Abstracts·2022Open Access
208 T-SIGn vector-mediated antigen “spray painting” and tumor microenvironment (TME) reprogramming to enable CAR-T cell targeting of solid tumors
Regular and Young Investigator Award Abstracts·2022Open Access
FORTITUDE: Results of a phase 1a study of the novel transgene-armed and tumor-selective vector NG-350A with and without pembrolizumab (pembro).
Journal of Clinical Oncology·2022· 2 cited
Safety and efficacy of the tumor-selective adenovirus enadenotucirev with or without paclitaxel in platinum-resistant ovarian cancer: a phase 1 clinical trial
Journal for ImmunoTherapy of Cancer·2021· 48 citedOpen Access
1011P FORTITUDE phase I study of NG-350A, a novel tumour-selective adenoviral vector expressing an anti-CD40 agonist antibody: Monotherapy dose escalation results
Annals of Oncology·2021· 5 cited
Abstract 1582: T-SIGn cancer gene therapy and anti-EGFR CAR-T cells synergize in combination therapy to clear A549 lung tumor xenografts and lung metastases in NSG mice
Cancer Research·2021
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Frequent Co-authors

Anne Cooke(9), Leonard W. Seymour(7), Kerry D. Fisher(5), David C. Rayner(5), I M Roitt(5), Patricia Hutchings(5), Grahame J. McKenzie(5), Jonathan R. Lamb(5), Margaret J. Dallman(5), Margaret R. Duffy(4), Janet Lei-Rossmann(4), Kerry Fisher(4), John Beadle(4), Kevin Page(4), Kim Dawe(4), George A. Ward(4), A. Robin Poole(4), Edward D. Zanders(4), Elaine Bolton(4), Roberto Solari(4)