Luigi Ferrucci

National Institutes of Health — United States

Medicine · Health Sciences

236h-index273.5kcitations2.6kworks9.02yr avg
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Research Topics

Nutrition and Health in Aging(355), Frailty in Older Adults(243), Genetic Associations and Epidemiology(152), Dementia and Cognitive Impairment Research(146), Nutritional Studies and Diet(138)

Publications2.5k total

Age-related decline of chaperone-mediated autophagy in skeletal muscle leads to progressive myopathy
Nature Metabolism·2025· 3 citedOpen Access
Early axonal degeneration linked to clinical decline in Alzheimer’s disease progression revealed with diffusion MRI
Journal of Clinical Investigation·2025· 1 citedOpen Access
<scp>DNA</scp> Methylation Signatures of Systemic Inflammation Are Associated With Brain Volume, Cognitive Trajectories, and Long‐Term Dementia Risk
Aging Cell·2025· 1 citedOpen Access
Electron Microscopy and Multi‐Omics Reveal Mitochondrial Dysfunction and Structural Remodeling in the Hearts of Elderly Mice
Aging Cell·2025Open Access
Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression
Experimental Physiology·2025Open Access
Plasma p-tau217 and incident mild cognitive impairment and dementia in older women: 25-year prospective study in The Women’s Health Initiative Memory Study
2025· 1 citedOpen Access
Understanding changes in complex care needs over time: key research insights into multimorbidity trajectories
The Lancet Healthy Longevity·2025Open Access
Retraction Note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
Nature·2025Open Access
The predictive power of brain-predicted age and leg strength on mobility decline in aging: findings from the Baltimore Longitudinal Study of Aging
The Journals of Gerontology Series A·2025Open Access
EMito-Metrix enables automated evaluation of mitochondrial morphology across species
Nature Metabolism·2025
Preservation of Autophagy May Be a Mechanism Behind Healthy Aging
Aging Cell·2025Open Access
Association of Skeletal Muscle Function Deficit (SMFD) with Performance, Disability, Frailty Phenotype, Hospitalization, and Falls: Results from the <i>InCHIANTI</i> Study
2025Open Access
Brain–heart–eye axis revealed by multi-organ imaging genetics and proteomics
Nature Biomedical Engineering·2025· 4 citedOpen Access
Total Cholesterol and Mortality in Older Adults: A Sex-Stratified Cohort Study
Nutrients·2025· 2 citedOpen Access
Daily steps and all-cause mortality: a meta-analysis of 15 international cohorts
UNC Libraries·2025Open Access
A distinct population of CD8+ T cells expressing CD39 and CD73 accumulates with age and supports cancer progression
Nature Aging·2025· 3 cited
Pitfalls of defacing whole-head MRI: re-identification risk with diffusion models and compromised research potential
Computers in Biology and Medicine·2025
Rising Energetic Cost Of Walking Predicts Cognitive Impairment
Medicine & Science in Sports & Exercise·2025
Dual decline in cognition and gait speed is associated with lower myelin content across age
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition·2025
Metabolomic Signatures of Extreme Old Age: Findings from the New England Centenarian Study
2025Open Access
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Frequent Co-authors

Jack M. Guralnik(19), Stefania Bandinelli(9), Robert B. Wallace(6), Lifang Hou(6), Andrea Baccarelli(6), John E. Morley(6), Timothy M. Frayling(5), David Melzer(5), Linda P. Fried(5), Ake T. Lu(5), Themistocles L. Assimes(5), Yun Li(5), Steve Horvath(5), Stephanie A. Studenski(5), Albert Hofman(5), Toshiko Tanaka(5), Matteo Cesari(5), Francesco Landi(5), Eleanor M. Simonsick(4), Austin Quach(4)