Maria Spies

University of Iowa — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

37h-index4.2kcitations216works3.42yr avg
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Research Topics

DNA Repair Mechanisms(95), DNA and Nucleic Acid Chemistry(55), Seismic Waves and Analysis(47), Methane Hydrates and Related Phenomena(40), Earthquake Detection and Analysis(39)

Publications209 total

Iron-oxide nanoparticles selectively enhance the toxicity of pharmacological ascorbate through hydrogen peroxide-dependent DNA damage in non-small cell lung cancer (NSCLC)
Free Radical Biology and Medicine·2025· 2 cited
The RAD52 double-ring remodels replication forks restricting fork reversal
Nature·2025· 7 citedOpen Access
Single-molecule analysis of PARP1-G-quadruplex interaction
2025· 1 citedOpen Access
The human RAD52 complex undergoes phase separation and facilitates bundling and end-to-end tethering of RAD51 presynaptic filaments
2024· 1 citedOpen Access
Human hnRNPA1 reorganizes telomere-bound replication protein A
Nucleic Acids Research·2024· 2 citedOpen Access
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA
Nature Communications·2024· 8 citedOpen Access
Molecular basis of CRX/DNA recognition and stoichiometry at the Ret4 response element
Structure·2024· 4 citedOpen Access
Generation of site-specifically labelled fluorescent human XPA to investigate DNA binding dynamics during nucleotide excision repair
Methods·2024· 2 citedOpen Access
The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA
2024· 2 citedOpen Access
Trans-complementation by the RecB nuclease domain of RecBCD enzyme reveals new insight into RecA loading upon χ recognition
Nucleic Acids Research·2024· 8 citedOpen Access
Introducing <i>NAR Molecular Medicine</i>, a new journal in the <i>Nucleic Acids Research</i> family
NAR Molecular Medicine·2024Open Access
Generation of site-specifically labelled fluorescent human XPA to investigate DNA binding dynamics during nucleotide excision repair
2023Open Access
Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer
Antioxidants·2023· 11 citedOpen Access
A double-ring of human RAD52 remodels replication forks restricting fork reversal
2023· 5 citedOpen Access
Germline landscape of RPA1, RPA2 and RPA3 variants in pediatric malignancies: identification of RPA1 as a novel cancer predisposition candidate gene
Frontiers in Oncology·2023· 4 citedOpen Access
Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability
Cell·2023· 25 citedOpen Access
Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies
Redox Biology·2023· 7 citedOpen Access
Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies
2023Open Access
The distinct roles of MSH2 and MLH1 in basal-like breast cancer and immune modulation
2023· 2 citedOpen Access
Single-Molecule Analysis of the Improved Variants of the G-Quadruplex Recognition Protein G4P
International Journal of Molecular Sciences·2023· 5 citedOpen Access
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Frequent Co-authors

Masayoshi Honda(10), Stephen C. Kowalczykowski(6), S.V. Subramanyam(6), Robert A. Pugh(5), Colleen C. Caldwell(4), Taekjip Ha(4), Sarah R Hengel(4), Marc S. Wold(4), Isaac Cann(4), Eva Malacaria(4), Pietro Pichierri(4), Mark S. Dillingham(3), Jill M. Grimme(3), Yusuke Okuno(3), Colin G. Wu(3), Annapaola Franchitto(3), M. Todd Washington(3), Ronald J. Baskin(2), Richard Fishel(2), Nilisha Pokhrel(2)