Stephen Kalinowski

Bristol-Myers Squibb (Germany) — Germany

Medicine · Health Sciences

12h-index802citations20works0.02yr avg
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Research Topics

Pancreatic function and diabetes(8), Plant biochemistry and biosynthesis(6), Metabolism, Diabetes, and Cancer(5), Diet, Metabolism, and Disease(5), Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis(3)

Publications20 total

Discovery of liver-selective glucokinase activators comprising N-(4-alkylthiazol-2-yl)benzamides and N-(3-alkyl-1,2,4-thiadiazol-5-yl)benzamides for the treatment of metabolic disorders
Bioorganic & Medicinal Chemistry Letters·2025
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1<i>H</i>-pyrazol-1-yl)methyl)phosphonate (BMS-820132)
Journal of Medicinal Chemistry·2022· 9 citedOpen Access
Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA<sub>1</sub>) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases
Journal of Medicinal Chemistry·2021· 53 citedOpen Access
BMS-986327 as a novel PET imaging agent for assessment of LPA1 receptors in IPF
2019· 1 cited
LPA1 antagonist BMS-986278 for idiopathic pulmonary fibrosis: Preclinical pharmacological in vitro and in vivo evaluation
2019· 11 cited
A Pre-Steady State Analysis of Ligand Binding to Human Glucokinase:  Evidence for a Preexisting Equilibrium
Biochemistry·2007· 67 cited
A 2006 Pilot Study of Hydraulic Permit Compliance, Implementation, and Effectiveness in Region 6
2006· 2 cited
Mechanism of Inhibition of Yeast Squalene Synthase by Substrate Analog Inhibitors
Archives of Biochemistry and Biophysics·1999· 3 cited
Glucokinase Regulatory Protein May Interact With Glucokinase in the Hepatocyte Nucleus
Diabetes·1997· 142 cited
Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus
Diabetes·1997· 33 cited
National Satellite Test Bed (NSTB) Communication Network Architecture and Performance
1997
Expression of Human Hepatic Glucokinase in Transgenic Mice Liver Results in Decreased Glucose Levels and Reduced Body Weight
Diabetes·1997· 101 cited
Heterologous Expression and Characterization of Rat Liver Glucokinase Regulatory Protein
Diabetes·1996· 17 cited
Heterologous expression and characterization of rat liver glucokinase regulatory protein
Diabetes·1996· 5 cited
Orally Active Squalene Synthase Inhibitors:  Bis((acyloxy)alkyl) Prodrugs of the α-Phosphonosulfonic Acid Moiety
Journal of Medicinal Chemistry·1996· 48 cited
Yeast squalene synthase. A mechanism for addition of substrates and activation by NADPH
Journal of Biological Chemistry·1994· 34 citedOpen Access
Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.
Journal of Biological Chemistry·1992· 108 citedOpen Access
Effects of long-term administration of HMG-CoA reductase inhibitors on cholesterol synthesis in lens
Experimental Eye Research·1991· 15 cited
Abnormal Differentiation of Human Papillomavirus-Induced Laryngeal Papillomas
Archives of Otolaryngology - Head and Neck Surgery·1990· 49 cited
Tissue-selective acute effects of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase on cholesterol biosynthesis in lens.
Journal of Lipid Research·1989· 104 citedOpen Access

Frequent Co-authors

Kasim A. Mookhtiar(8), Peter T. W. Cheng(4), Shiwei Tao(4), Yan Shi(4), Bradley A. Zinker(4), Joseph R. Taylor(4), Karen Brown(3), Stephen T. Mosley(3), Yanou Yang(3), Carrie Xu(3), Bruce A. Ellsworth(3), Brian J. Murphy(3), Bernd Schäfer(2), Ryouichi Tanaka(2), Jovita Marcinkeviciene(2), Robert F. Kaltenbach(2), Jun Shi(2), Jun Li(2), Suresh Dhanusu(2), R. Ramesh Babu(2)