Gaochao Zhou

Shenyang Pharmaceutical University — China

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index12.4kcitations59works1.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Peroxisome Proliferator-Activated Receptors(21), Metabolism, Diabetes, and Cancer(18), Hormonal Regulation and Hypertension(12), Pancreatic function and diabetes(9), Adipose Tissue and Metabolism(9)

Publications59 total

Nanoassemblies of the redox paclitaxel prodrug with the natural active ingredient dihydroartemisinin for therapy of breast cancer
Nanoscale·2025· 1 cited
Ketohexokinase knockout mice, a model for essential fructosuria, exhibit altered fructose metabolism and are protected from diet-induced metabolic defects
American Journal of Physiology-Endocrinology and Metabolism·2018· 35 citedOpen Access
Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase
ACS Medicinal Chemistry Letters·2017· 56 citedOpen Access
Hit-to-Lead Optimization and Discovery of 5-((5-([1,1′-Biphenyl]-4-yl)-6-chloro-1 <i>H</i> -benzo[ <i>d</i> ]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase
Journal of Medicinal Chemistry·2017· 26 citedOpen Access
Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy
Science·2017· 329 cited
Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension
Bioorganic & Medicinal Chemistry Letters·2017· 23 citedOpen Access
Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension
ACS Medicinal Chemistry Letters·2016· 14 citedOpen Access
Discovery of novel non-steroidal reverse indole mineralocorticoid receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2016· 12 citedOpen Access
Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys
ACS Medicinal Chemistry Letters·2015· 18 citedOpen Access
Discovery of Benzimidazole CYP11B2 Inhibitors with <i>in Vivo</i> Activity in Rhesus Monkeys
ACS Medicinal Chemistry Letters·2015· 24 citedOpen Access
Discovery of Benzimidazole Oxazolidinediones as Novel and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists
ACS Medicinal Chemistry Letters·2015· 13 citedOpen Access
Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys - Supplementary Info
2015
Mineralocorticoid receptor antagonists: Identification of heterocyclic amide replacements in the oxazolidinedione series
Bioorganic & Medicinal Chemistry Letters·2014· 26 citedOpen Access
Clinical effects of early laparoscopic cholecystectomy for the patients with acute pancreatitis with gallbladder stone
Zhonghua gan-dan waike zazhi·2014
Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists
Bioorganic & Medicinal Chemistry Letters·2013· 16 citedOpen Access
Benzimidazolones: A New Class of Selective Peroxisome Proliferator-Activated Receptor γ (PPARγ) Modulators
Journal of Medicinal Chemistry·2011· 56 citedOpen Access
A strategy of employing aminoheterocycles as amide mimics to identify novel, potent and bioavailable soluble epoxide hydrolase inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 33 citedOpen Access
Discovery of 3,3-disubstituted piperidine-derived trisubstituted ureas as highly potent soluble epoxide hydrolase inhibitors
Bioorganic & Medicinal Chemistry Letters·2009· 24 citedOpen Access
Discovery of a Highly Potent, Selective, and Bioavailable Soluble Epoxide Hydrolase Inhibitor with Excellent Ex Vivo Target Engagement
Journal of Medicinal Chemistry·2009· 42 citedOpen Access
Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice
Diabetes·2009· 405 citedOpen Access
page 1 of 3Next →

Frequent Co-authors

David E. Moller(20), Joel P. Berger(15), Yuli Chen(10), Thomas W. Doebber(10), Karen L. MacNaul(10), Samuel D. Wright(9), Margaret Wu(8), Alex Elbrecht(7), Hong C. Shen(7), Xinchun Tong(6), Lee-Yuh Pai(6), Jack Gibson(6), Ying Li(5), John G. Menke(5), Carl P. Sparrow(5), Tian‐Quan Cai(5), Yu‐Sheng Chao(5), Xiaoping Zhang(5), James R. Tata(5), Iyassu K. Sebhat(4)