Ou Cao

University of Florida — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index1.3kcitations28works0.02yr avg
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Research Topics

Virus-based gene therapy research(23), CAR-T cell therapy research(16), Viral Infectious Diseases and Gene Expression in Insects(7), CRISPR and Genetic Engineering(6), Hemophilia Treatment and Research(5)

Publications28 total

Immune Tolerance Induction to Factor IX through B Cell Gene Transfer: TLR9 Signaling Delineates between Tolerogenic and Immunogenic B Cells
Molecular Therapy·2014· 31 citedOpen Access
Immune Tolerance Induction to Factor IX Through B Cell Gene Transfer – Delineating Between Tolerogenic and Immunogenic B Cells.
Blood·2012· 1 cited
Mapping the T helper cell response to acid α-glucosidase in Pompe mice
Molecular Genetics and Metabolism·2012· 19 citedOpen Access
Nonredundant Roles of IL-10 and TGF-β in Suppression of Immune Responses to Hepatic AAV-Factor IX Gene Transfer
Molecular Therapy·2011· 64 citedOpen Access
High Efficiency Ex Vivo Gene Transfer to Primary Murine B Cells Using Plasmid or Viral Vectors
Journal of Genetic Syndromes & Gene Therapy·2011· 13 citedOpen Access
Tolerance Induction to B Domain-Deleted and Full-Length F.VIII by Co-Administration with Rapamycin
Blood·2010· 23 cited
Two decades of clinical gene therapy--success is finally mounting.
PubMed·2010· 75 cited
Impact of the Underlying Mutation and the Route of Vector Administration on Immune Responses to Factor IX in Gene Therapy for Hemophilia B
Molecular Therapy·2009· 90 citedOpen Access
Prophylactic immune tolerance induced by changing the ratio of antigen‐specific effector to regulatory T cells
Journal of Thrombosis and Haemostasis·2009· 64 citedOpen Access
Role of regulatory T cells in tolerance to coagulation factors
Journal of Thrombosis and Haemostasis·2009· 53 citedOpen Access
Improved Induction of Immune Tolerance to Factor IX by Hepatic AAV-8 Gene Transfer
Human Gene Therapy·2009· 88 citedOpen Access
A Prophylactic Protocol for the Prevention of Inhibitor Formation in Gene Therapy for Hemophilia B by Shifting the Balance from An Effector to a Regulatory T Cell Response
Blood·2008
TLR3 signaling does not affect organ-specific immune responses to factor IX in AAV gene therapy
Blood·2008· 6 citedOpen Access
Emerging Role of Regulatory T Cells in Gene Transfer
Current Gene Therapy·2007· 26 cited
Muscle as a Target for Supplementary Factor IX Gene Transfer
Human Gene Therapy·2007· 43 cited
Induction and role of regulatory CD4+CD25+ T cells in tolerance to the transgene product following hepatic in vivo gene transfer
Blood·2007· 213 citedOpen Access
Regulatory CD4+CD25+ T Cells Are Required for Tolerance Induction to Factor IX by In Vivo Gene Transfer.
Blood·2006
Gene therapy for treatment of inherited haematological disorders
Expert Opinion on Biological Therapy·2006· 13 cited
Immune deviation by mucosal antigen administration suppresses gene-transfer–induced inhibitor formation to factor IX
Blood·2006· 34 citedOpen Access
Prevention of cytotoxic T lymphocyte responses to factor IX-expressing hepatocytes by gene transfer-induced regulatory T cells
Proceedings of the National Academy of Sciences·2006· 104 citedOpen Access
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Frequent Co-authors

Roland W. Herzog(26), Lixin Wang(9), Eric Dobrzynski(8), Sushrusha Nayak(7), Brad E. Hoffman(6), Federico Mingozzi(5), Babak Moghimi(5), Katherine A. High(4), Mario Cooper(3), Brandon K. Sack(3), Elina Armstrong(3), Bianca M. Conti‐Fine(3), Irene Zolotukhin(3), Bethany Mingle(2), Julie C. Fitzgerald(2), Alexander Schlachterman(2), Cox Terhorst(2), Mark A. Atkinson(2), Xiaomei Wang(2), Cox Terhorst(1)