Knut R. Steffensen

Karolinska Institutet — Sweden

Medicine · Health Sciences

48h-index6.6kcitations118works2.02yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Cholesterol and Lipid Metabolism(88), Drug Transport and Resistance Mechanisms(35), Peroxisome Proliferator-Activated Receptors(28), Lipid metabolism and biosynthesis(19), Cancer, Lipids, and Metabolism(16)

Publications118 total

Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses
Advanced Science·2024· 2 citedOpen Access
Liver X receptors induce antiproliferative effects in basal‐like breast cancer
Molecular Oncology·2023· 3 citedOpen Access
Author response for "Liver X receptors induce antiproliferative effects in basal‐like breast cancer"
2023
Author response for "Liver X receptors induce antiproliferative effects in basal‐like breast cancer"
2023
Soat2 ties cholesterol metabolism to β-oxidation and glucose tolerance in male mice
Oxford University Research Archive (ORA) (University of Oxford)·2022· 19 citedOpen Access
Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
Journal of Autoimmunity·2021· 18 citedOpen Access
Srebf1 Controls Midbrain Dopaminergic Neurogenesis
Cell Reports·2020· 30 citedOpen Access
Insights From Liver‐Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR‐Agonist Pharmacodynamics in Humans
Hepatology·2019· 35 citedOpen Access
Diiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity
Molecular and Cellular Endocrinology·2019· 10 cited
Reduction Of Bile Acid Synthesis And Intrahepatic Lipid Accumulation In Liver-Humanized Mice Define The Unfavorable Pharmacodynamics Of Lxr Agonism In Humans
Atherosclerosis·2019
Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function
Frontiers in Immunology·2019· 53 citedOpen Access
Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease
Cell Reports·2019· 65 citedOpen Access
Genetic depletion of Soat2 diminishes hepatic steatosis via genes regulating de novo lipogenesis and by GLUT2 protein in female mice
Digestive and Liver Disease·2018· 13 cited
Nuclear receptor ligands induce TREM-1 expression on dendritic cells: analysis of their role in tumors
OncoImmunology·2018· 17 citedOpen Access
Genetic depletion of the Soat2 gene diminishes diet-induced hepatic steatosis and improves glucose tolerance in mice
Atherosclerosis·2018
Liver-humanized mice exhibit lipoprotein-specific phenotypes when grafted with human hepatocytes from different donors
Atherosclerosis·2017· 1 cited
Changes in LXRα phosphorylation promote a novel diet-induced transcriptome that alters the transition from fatty liver to steatohepatitis
2017Open Access
Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice
Immunity Inflammation and Disease·2016· 22 citedOpen Access
The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms
Scientific Reports·2016· 49 citedOpen Access
The nuclear receptor LXR modulates interleukin-18 levels through multiple mechanisms
RVC Research Online (Royal Veterinary College)·2016Open Access
page 1 of 6Next →

Frequent Co-authors

Jan-Ακε Gustafsson(29), Eckardt Treuter(10), Tomas Jakobsson(7), Paolo Parini(7), Thomas M. Stulnig(6), Gertrud U. Schuster(5), Nicolas Venteclef(5), Jan-Åke Gustafsson(4), Catia Traversari(3), Vincenzo Russo(3), Anna Ehrlund(3), Anastasios Damdimopoulos(3), Spyridon Theofilopoulos(3), Ernest Arenas(3), Lise‐Lotte Vedin(3), Markku Pelto‐Huikko(3), Marion Korach-André(3), Eduardo J. Villablanca(2), Laura Raccosta(2), Raffaella Fontana(2)