Donald J. Kyle

Purdue Pharma (United States) — United States

Medicine · Health Sciences

27h-index2.1kcitations83works0.02yr avg
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Research Topics

Coagulation, Bradykinin, Polyphosphates, and Angioedema(25), Chemical Synthesis and Analysis(19), Neuropeptides and Animal Physiology(18), Receptor Mechanisms and Signaling(16), Monoclonal and Polyclonal Antibodies Research(8)

Publications83 total

The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia
Journal of Clinical Investigation·2023· 11 citedOpen Access
Meet the Editorial Board Member
Current Bioactive Compounds·2022
0001 Activation of Nociceptin/Orphanin-FQ Peptide (NOP) Receptors Produces an Increase in Non-REM Sleep in Rats and Constitutes a Novel and Attractive Target for the Treatment of Insomnia
SLEEP·2020Open Access
Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis
Pharmacology & Therapeutics·2020· 145 citedOpen Access
Meet Our Editorial Board Member
Current Bioactive Compounds·2018
Bradykinin Receptor Antagonists
2018
N-Aryl azacycles as novel sodium channel blockers
Bioorganic & Medicinal Chemistry Letters·2014· 11 citedOpen Access
Dibenzazepines and dibenzoxazepines as sodium channel blockers
Bioorganic & Medicinal Chemistry Letters·2014· 16 citedOpen Access
Structure–Activity Relationship Studies and Discovery of a Potent Transient Receptor Potential Vanilloid (TRPV1) Antagonist 4-[3-Chloro-5-[(1<i>S</i>)-1,2-dihydroxyethyl]-2-pyridyl]-<i>N</i>-[5-(trifluoromethyl)-2-pyridyl]-3,6-dihydro-2<i>H</i>-pyridine-1-carboxamide (V116517) as a Clinical Candidate for Pain Management
Journal of Medicinal Chemistry·2014· 24 cited
Studies Examining the Relationship between the Chemical Structure of Protoxin II and Its Activity on Voltage Gated Sodium Channels
Journal of Medicinal Chemistry·2014· 49 citedOpen Access
Biased Agonism Of The Mu Opioid Receptor. An Emerging Approach Toward Separation Of Analgesia and Side Effects.
2013
A Review of the NOP (ORL-1)-Nociceptin/Orphanin FQ System Covering Receptor Structure, Distribution, Role in Analgesia and Reward and Interactions with Other Receptors
ACS symposium series·2013· 8 cited
Functionally Biased Agonism of Mu and Kappa Opioid Receptors
ACS symposium series·2013· 2 cited
Roles of μ-Opioid Receptors and Nociceptin/Orphanin FQ Peptide Receptors in Buprenorphine-Induced Physiological Responses in Primates
Journal of Pharmacology and Experimental Therapeutics·2012· 95 citedOpen Access
Cysteine racemization during the Fmoc solid phase peptide synthesis of the Nav1.7‐selective peptide – protoxin II
Journal of Peptide Science·2012· 15 cited
Roles of MOP and NOP receptors in regulating buprenorphine‐induced physiological responses in monkeys
The FASEB Journal·2012
Sodium Channel Blockers.
ChemInform·2007
Sodium Channel Blockers
Journal of Medicinal Chemistry·2007· 44 citedOpen Access
TRPV1 antagonists: a survey of the patent literature
Expert Opinion on Therapeutic Patents·2006· 22 cited
Editorial [ Efficient Medicinal Chemistry (Guest Editor: Donald J. Kyle)]
Combinatorial Chemistry & High Throughput Screening·2006
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Frequent Co-authors

Sarvajit Chakravarty(7), Ronald M. Burch(7), Laykea Tafesse(6), Kenneth J. Valenzano(6), Qun Sun(5), Xiaoming Zhou(5), João Β. Calixto(4), Babu Mavunkel(4), Kevin P. Carlin(4), Yakov Rotshteyn(4), Wendy Miller(4), Qiang Zheng(4), Chongwu Zhang(3), L.M. Fredrik Leeb-Lundberg(3), Victor I. Ilyin(3), Khondaker Islam(3), Aniket Patel(3), R. Richard Goehring(3), Zhengming Chen(3), Shen Shan(3)