Sarkis S. Margossian

Royal Veterinary College — United Kingdom

Medicine · Health Sciences

18h-index2.3kcitations37works0.02yr avg
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Research Topics

Cardiomyopathy and Myosin Studies(23), Muscle Physiology and Disorders(8), Cardiovascular Effects of Exercise(7), Viral Infections and Immunology Research(6), Muscle metabolism and nutrition(4)

Publications37 total

Locking Regulatory Myosin in the Off-state with Trifluoperazine
Journal of Biological Chemistry·2000· 21 citedOpen Access
Myofibrillar protein structure and assembly during idiopathic dilated cardiomyopathy
Molecular and Cellular Biochemistry·1999· 8 cited
Calcium regulation in the human myocardium affected by dilated cardiomyopathy: A structural basis for impaired Ca2+-sensitivity
Molecular and Cellular Biochemistry·1999· 18 cited
Cloning of the cDNA and nucleotide sequence of a skeletal muscle protease from myopathic hamsters
Molecular and Cellular Biochemistry·1998· 6 cited
Human cardiac myosin light chains: Sequence comparisons between myosin LC1 and LC2 from normal and idiopathic dilated cardiomyopathic hearts
Molecular and Cellular Biochemistry·1995· 5 cited
Physical characterization of recombinant tissue plasminogen activator
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology·1993· 15 cited
Kinetics of hydrolysis of cardiac S1 heavy chain isoforms and identification of light chain and acting binding sites
Cardiovascular Research·1993· 2 cited
Functional effects of LC1-reassociation with cardiac papain Mg � S1
Journal of Muscle Research and Cell Motility·1993· 15 cited
Light chain 2 profile and activity of human ventricular myosin during dilated cardiomyopathy. Identification of a causal agent for impaired myocardial function.
Circulation·1992· 86 cited
Influence of the cardiac myosin hinge region on contractile activity.
Proceedings of the National Academy of Sciences·1991· 28 citedOpen Access
Physical characterization of histidine-rich protein from Plasmodium lophurae
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology·1990· 11 cited
Formation of new quasi-crystalline ordered aggregates by gizzard myosin
Journal of Muscle Research and Cell Motility·1989· 3 cited
Electron microscopy of cardiac myosin: Its shape and properties as determined by the regulatory light chain
Journal of Muscle Research and Cell Motility·1987· 16 cited
Control of filament length by the regulatory light chains in skeletal and cardiac myosins.
Journal of Biological Chemistry·1987· 18 citedOpen Access
Physico-chemical properties of rat and dog cardiac α-actinin
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology·1986· 20 cited
Isolation and partial characterization of endothelial cell extracellular complexes
Journal of Cellular Physiology·1986· 7 cited
Reversible dissociation of dog cardiac myosin regulatory light chain 2 and its influence on ATP hydrolysis.
Journal of Biological Chemistry·1985· 51 citedOpen Access
Proteolytic susceptibility of both isolated and bound light chains from various myosins to myopathic hamster protease.
Journal of Biological Chemistry·1984· 9 citedOpen Access
Role of the regulatory light chains in skeletal muscle actomyosin ATPase and in minifilament formation.
Journal of Biological Chemistry·1983· 40 citedOpen Access
Oxygen-exchange studies on the pathways for magnesium adenosine 5'-triphosphate hydrolysis by actomyosin
Biochemistry·1983· 17 cited
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Frequent Co-authors

Henry S. Slayter(16), Susan Lowey(6), James Caulfield(6), Walter F. Stafford(5), Peter D. Chantler(5), Paul Norton(4), Ashwani Malhotra(3), Richard L. McCarl(3), John Clifford Holt(3), Carolyn Cohen(2), Howard D. White(2), Pamela A. Norton(2), Susan Taylor(2), Hitesh Patel(2), Mark R. Deziel(2), Patrick K. Umeda(2), James R. Sellers(2), Victor B. Hatcher(2), Bruce A. Barshop(1), John Lawler(1)