Colin D. Medley

Synthetic Biologics (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index3.4kcitations36works0.02yr avg
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Research Topics

Advanced biosensing and bioanalysis techniques(18), Monoclonal and Polyclonal Antibodies Research(14), HER2/EGFR in Cancer Research(9), Advanced Biosensing Techniques and Applications(9), RNA Interference and Gene Delivery(8)

Publications36 total

Automated online deconjugation of antibody-drug conjugate for small molecule drug profiling
Journal of Chromatography A·2023· 1 cited
Automated Online Deconjugation of Antibody-Drug Conjugate for Small Molecule Drug Profiling
SSRN Electronic Journal·2023Open Access
Quantitation of Conjugation-related Residual Solvents in Antibody Drug Conjugates using Headspace Gas Chromatography
Current Pharmaceutical Analysis·2020· 1 cited
Antibody-drug conjugate characterization by chromatographic and electrophoretic techniques
Journal of Chromatography B·2016· 62 cited
A Small-scale Model to Assess the Risk of Leachables from Single-use Bioprocess Containers through Protein Quality Characterization
PDA Journal of Pharmaceutical Science and Technology·2016· 7 cited
Investigation of low recovery in the free drug assay for antibody drug conjugates by size exclusion—reversed phase two dimensional-liquid chromatography
Journal of Chromatography B·2016· 14 cited
An enzymatic deconjugation method for the analysis of small molecule active drugs on antibody-drug conjugates
mAbs·2016· 42 citedOpen Access
Process Development of the Synthesis and Purification of a Reactive Immuno-PET Conjugate Intermediate
Organic Process Research & Development·2016· 5 cited
Chemical de-conjugation for investigating the stability of small molecule drugs in antibody-drug conjugates
Journal of Pharmaceutical and Biomedical Analysis·2015· 27 cited
A size exclusion-reversed phase two dimensional-liquid chromatography methodology for stability and small molecule related species in antibody drug conjugates
Journal of Chromatography A·2015· 64 cited
Characterizing changes in protein quality attributes to assess leachable risks from single-use bioprocess containers
2015
Quantification of residual solvents in antibody drug conjugates using gas chromatography
Analytica Chimica Acta·2014· 19 cited
Limiting degradation of reactive antibody drug conjugate intermediates in HPLC method development
Journal of Pharmaceutical and Biomedical Analysis·2014· 9 cited
Detection of residual biocides in antibody drug conjugates for ImmunoPET imaging
Analytical Methods·2014· 4 cited
Turning on Lanthanide Luminescence via Nanoencapsulation
Inorganic Chemistry·2013· 22 cited
Molecular Beacons for Intracellular Analysis: Challenges and Successes
2013
A DNA-conjugated magnetic nanoparticle assay for assessing genotoxicity
Analytical and Bioanalytical Chemistry·2012· 6 cited
Aptamer-Conjugated Nanoparticles for Cancer Cell Detection
Analytical Chemistry·2011· 181 citedOpen Access
Quantitation of plasmid DNA deposited on gold particles for particle-mediated epidermal delivery using ICP-MS
Analytical and Bioanalytical Chemistry·2010· 5 citedOpen Access
Locked Nucleic Acid Based Beacons for Surface Interaction Studies and Biosensor Development
Analytical Chemistry·2009· 66 citedOpen Access
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Frequent Co-authors

Weihong Tan(17), Jason Gruenhagen(10), Chaoyong Yang(7), Nik P. Chetwyn(7), Joshua E. Smith(6), Peter Yehl(5), Yanrong Wu(4), Hui Lin(4), Tao Chen(4), Dihua Shangguan(3), Zhiwen Tang(3), Lin Wang(3), Richard J. Rogers(3), Christine Gu(3), Kelly Zhang(3), Yi Li(3), Kemin Wang(2), Zhiwen Tang(2), Youngmi Kim(2), Xiaohong Fang(2)