Patrick Brassil

Theravance Biopharma (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

22h-index1.8kcitations40works0.02yr avg
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Research Topics

Cancer therapeutics and mechanisms(9), Pharmacogenetics and Drug Metabolism(8), Cancer-related Molecular Pathways(7), Drug Transport and Resistance Mechanisms(5), DNA Repair Mechanisms(4)

Publications40 total

Lung-restricted ALK5 inhibition avoids systemic toxicities associated with TGFβ pathway inhibition
Toxicology and Applied Pharmacology·2022· 10 citedOpen Access
Gut-Selective Design of Orally Administered Izencitinib (TD-1473) Limits Systemic Exposure and Effects of Janus Kinase Inhibition in Nonclinical Species
Toxicological Sciences·2022· 13 citedOpen Access
Pharmacokinetics of TD-8236, a Lung-Selective pan-JAK Inhibitor, Following Single-Dose Administration in Mice, Rats, and Dogs
2021Open Access
Development of Gut-Selective Pan-Janus Kinase Inhibitor TD-1473 for Ulcerative Colitis: A Translational Medicine Programme
Journal of Crohn s and Colitis·2020· 81 citedOpen Access
Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254)
Bioorganic & Medicinal Chemistry·2019Open Access
Adventures in Scaffold Morphing: Discovery of Fused Ring Heterocyclic Checkpoint Kinase 1 (CHK1) Inhibitors
Journal of Medicinal Chemistry·2018· 28 citedOpen Access
Intestinally-restricted Janus Kinase inhibition: a potential approach to maximize the therapeutic index in inflammatory bowel disease therapy
Journal of Inflammation·2017· 24 citedOpen Access
CCDC 1013311: Experimental Crystal Structure Determination
The Cambridge Structural Database·2015Open Access
Novel DNA Gyrase Inhibiting Spiropyrimidinetriones with a Benzisoxazole Scaffold: SAR and in Vivo Characterization
Journal of Medicinal Chemistry·2014· 55 citedOpen Access
Biotransformation and bioactivation reactions of alicyclic amines in drug molecules
Drug Metabolism Reviews·2014· 78 cited
Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT6 antagonists
Bioorganic & Medicinal Chemistry·2014· 22 citedOpen Access
A novel uHPLC–MS/MS method for the quantitation of AZD7451 (AZ12607092) in human plasma
Journal of Chromatography B·2013· 1 citedOpen Access
Metabolism and pharmacokinetic optimization strategies in drug discovery
Drug Discovery and Development·2013· 14 cited
Contributors
Drug Discovery and Development·2013
Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced p<i>K</i><sub>a</sub>: Antibacterial Agents with an Improved Safety Profile
Journal of Medicinal Chemistry·2012· 88 citedOpen Access
The right compound in the right assay at the right time: an integrated discovery DMPK strategy
Drug Metabolism Reviews·2012· 60 cited
Discovery of Checkpoint Kinase Inhibitor (<i>S</i>)-5-(3-Fluorophenyl)-<i>N</i>-(piperidin-3-yl)-3-ureidothiophene-2-carboxamide (AZD7762) by Structure-Based Design and Optimization of Thiophenecarboxamide Ureas
Journal of Medicinal Chemistry·2012· 67 citedOpen Access
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO
Bioorganic & Medicinal Chemistry Letters·2012· 18 citedOpen Access
Abstract 3770: PK/PD/Efficacy characterization of AZ285, a selective CK2 kinase inhibitor
Cancer Research·2012· 1 cited
Abstract 3907: Discovery and characterization of AZ285 as a potent and selective inhibitor of CK2 kinase
Cancer Research·2012· 2 cited
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Frequent Co-authors

Paul D. Lyne(9), Chun Deng(7), James W. Janetka(7), Vibha Oza(6), Susan Ashwell(6), Dorin Toader(6), Sonya Zabludoff(6), J. Breed(5), Candice L. Horn(5), Dingwei Yu(5), Wendy Clarke(4), Stephanos Ioannidis(4), Nicholas J. Newcombe(4), Martin Pass(4), Jon Read(4), Mei Su(4), Melissa M. Vasbinder(4), Yan Yu(4), Peter J. H. Webborn(4), Daniel Russell(4)