J. G. Coen van Hasselt

Leiden University — Netherlands

Medicine · Health Sciences

33h-index3.8kcitations166works3.52yr avg
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Research Topics

Antibiotics Pharmacokinetics and Efficacy(33), Antibiotic Resistance in Bacteria(17), Drug Transport and Resistance Mechanisms(16), Computational Drug Discovery Methods(14), Pneumonia and Respiratory Infections(13)

Publications166 total

The influence of heteroresistance, growth and antibiotic selection in shaping the invasion dynamics of colistin resistant <i>Pseudomonas aeruginosa</i>
2025Open Access
Aggregate data modelling: A fast implementation for fitting pharmacometrics models to summary-level data in R
Journal of Pharmacokinetics and Pharmacodynamics·2025
Model-based optimisation for teicoplanin dosing in patients undergoing maintenance haemodialysis
Clinical Microbiology and Infection·2025
Aggregate data modelling: a fast implementation for fitting pharmacometrics models to summary-level data in R
2025Open Access
Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety
Nature Reviews Drug Discovery·2025· 2 cited
Spatial Pharmacokinetic and Pharmacodynamic Modeling in Airway Mucus
Clinical Pharmacokinetics·2025Open Access
Late treatment initiation leads to reduced antiviral potency
2025Open Access
Colistin resistance dynamics in <i>Pseudomonas aeruginosa</i> under biofilm and planktonic growth
Antimicrobial Agents and Chemotherapy·2025Open Access
Nutrients drive the antibiotic-specific evolution of resistance in Pseudomonas aeruginosa
Research in Microbiology·2025Open Access
Mechanistic viral dynamic modelling of in vitro cytomegalovirus infection based on viral DNA and viral titre
British Journal of Clinical Pharmacology·2025Open Access
Beta-endorphin is the key endogenous opioid influencing morphine µ-opioid receptor occupancy in rat hypothalamus: a binding kinetic model analysis
European Journal of Pharmaceutical Sciences·2025· 1 citedOpen Access
Integrating Pharmacokinetics and Quantitative Systems Pharmacology Approaches in Generative Drug Design
Journal of Chemical Information and Modeling·2025· 5 citedOpen Access
Target attainment of benzylpenicillin in patients with infective endocarditis
Clinical Microbiology and Infection·2025Open Access
Integrating Pharmacokinetics and Quantitative Systems Pharmacology Approaches in Generative Drug Design
2025Open Access
Correction: Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post‑Hoc Analysis
Clinical Pharmacokinetics·2025Open Access
The endocannabinoid 2-arachidonoylglycerol is released and transported on demand via extracellular microvesicles
Proceedings of the National Academy of Sciences·2025· 12 citedOpen Access
Prediction of the Extent of Blood–Brain Barrier Transport Using Machine Learning and Integration into the LeiCNS-PK3.0 Model
Pharmaceutical Research·2025· 2 citedOpen Access
Pharmacodynamics of interspecies interactions in polymicrobial infections
npj Biofilms and Microbiomes·2025· 6 citedOpen Access
Clinical Pharmacokinetics of N,N-Dimethyltryptamine (DMT): A Systematic Review and Post-hoc Analysis
Clinical Pharmacokinetics·2025· 6 citedOpen Access
Integrating Pharmacokinetics and Quantitative Systems Pharmacology Approaches in Generative Drug Design
2025· 1 citedOpen Access
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Frequent Co-authors

Alwin D. R. Huitema(10), Jan H.M. Schellens(8), Piet H. van der Graaf(7), Jos H. Beijnen(6), Meindert Danhof(5), Catherijne A. J. Knibbe(4), Linda B. S. Aulin(4), M. de Kam(3), Thomas Hankemeier(3), Ravi Iyengar(3), Yumi Yamamoto(3), Pyry A. J. Välitalo(3), Yin Cheong Wong(3), Dymphy Huntjens(3), Johannes H. Proost(3), An Vermeulen(3), Walter Krauwinkel(3), Elizabeth C. M. de Lange(3), Gomathi Jayaraman(3), Jaehee V. Shim(3)